摘要
目的 探讨老年高血压与血小板活性的关系 ,钙拮抗剂对血小板活性的影响及其在高血压病治疗中的意义。方法 采用流式细胞仪检测老年高血压患者氨氯地平治疗前后与对照组的血小板胞浆内 [Ca2 + ] ,与采用放射免疫法测定血浆TXB2 和 6 k PGF1α。结果 高血压组血小板胞浆内 [Ca2 + ] ,血浆TXB2 明显高于正常对照组。血浆 6 k PGF1α明显低于正常对照组 (P均 <0 0 0 1 )。高血压组用药后血小板胞浆内 [Ca2 + ]血浆TXB2 明显低于用药前 ,6 k PGF1α明显高于用药前 (P均 <0 0 0 1 )。结论 老年高血压患者血小板活性增强 ,用钙离子拮抗剂氨氯地平治疗后可显著降低血小板活性 。
Objective To study the ralationship between platelet activity in elderly hypertension and the effect of calcium antagonistic agents on platelet activity. Methods Thirty inpatients with essential hypertensive were selected as treatment group and 20 health subjects as control. The platelet intracellular calcium concentration were measured by flow cytometry. Plasma TXB 2 and 6 k PGF 1α were assayed by radioimmunoassay. These parameters were reexamined in treatment group after 8 weeks of amlodopime treatment. Result The platelet [Ca 2+ ], plasma TXB 2 are higher and 6 k PGF 1α is significantly lower in treatment group than that of control group ( P <0 001);[Ca 2+ ] and TXB 2 were decreased after amlodipine treatment, while 6 k PGF 1α increased( P <0 001). Conclusion The platelet activity was increased in elder hypertensive patients. The calcium antagonistic agents amlodipine decreases the activity of platelet.
出处
《高血压杂志》
CSCD
2002年第2期107-109,共3页
Chinese Journal of Hypertension
基金
国家九五攻关课题
