摘要
目的 :观察雷公藤多甙联合小剂量甲氨蝶呤治疗老年性类风湿性关节炎的疗效和不良反应。方法 :将 60例老年性类风湿性关节炎患者随机分成两组 ,治疗组 30例 ,予以雷公藤多甙 1 0 mg,每日 3次 ,甲氨蝶呤 7.5 mg,每周 1次。对照组 30例 ,服用甲氨蝶呤 1 5 mg,每周 1次 ,疗程均为 3个月。结果 :治疗组总有效率 86.67% ,对照组总有效率 83.33%。两组疗效无差异 ( P>0 .0 5 ) ,但治疗组在改善患者的关节压痛指数、关节肿胀指数、晨僵、血沉等方面优于对照组 ( P<0 .0 1或P<0 .0 5 )。治疗组不良反应发生率为 2 6.67 ,对照组 43.33 ,两组相比差异有显著性意义( P<0 .0 1 )。结论 :雷公藤多甙联合小剂量甲氨蝶呤可适用于治疗老年性类风湿性关节炎。
Objective: To observe the therapeutic efficacy and side effects of Tripterygium glycosides combined with low dosage of methopterin in treating rheumatoid arthritis cases.Methods:60 senile rheumatoid arthritis cases were divided into 2 groups: Tripterygium glycosides group (treated with Tripterygium glycosides, 10 mg, 3 times a day. Methopterin 7.5 mg, once a week for 3 months) and control group (Methopterin 15 mg, once a week for 3 months). Results: The total effective rate 86.67% in the Tripterygium glycosides group and 83.33% in the control group. Joints tenderness and swelling relieving was better in the Tripterygium glycosides group than in the control group ( P <0.05). Conclusion:Tripterygium glycosides group and low dosage of methopterin were effective in treating senilerheumatoid arthritis cases.
出处
《浙江中西医结合杂志》
2002年第6期334-336,共3页
Zhejiang Journal of Integrated Traditional Chinese and Western Medicine
