摘要
目的 :探讨白芍总甙 (TGP)对离体豚鼠结肠平滑肌的作用方式及对结肠平滑肌中 P物质 (SP)和血管活性肠肽 (VIP)释放的影响。方法 :观察不同剂量 TGP及工具药对离体结肠肌收缩活性的效应及利用 SABC法检测结肠平滑肌中 SP和血管 VIP的变化。结果 :TGP使豚鼠结肠离体平滑肌收缩积分和时间显著性增加 ,且收缩效应的改变具有剂量依赖性。平滑肌中 SP的反应显著性增强。结论 :TGP可通过延长结肠收缩时间 ,增强结肠收缩幅度而调节结肠运动 ,SP是 TGP作用的递质之一。
Objective:To explore the effect of total glucosides of Paeony(TGP)on ex vivo colon smooth muscle of Guines pig and the release of SP and VIP in colon smooth muscle. Methods: The contraction activity of ex vivo colon traverse and longitudinal muscle strips was observed respectively at different dosage of TGP and other medicine. SP and VIP in colon of Guinea pig were tested by SABC.Results: TGP could significantly increase the contraction integral and time of the colon traverse and longitudinal muscle strips.The change of contraction was dosage independent. The number of cell with SP was increased significantly.Conclusion: TGP can regulate the motility of colon of Guinea pig by lengthening the time of contraction and reinforcing the extent of contraction.SP is one of the transmitters during the action of TGP.
出处
《中国中西医结合消化杂志》
CAS
2002年第3期151-153,共3页
Chinese Journal of Integrated Traditional and Western Medicine on Digestion
