摘要
目的:探讨慢性乙型肝炎患者长期口服联苯双酯的抗病毒作用及安全性,为慢性乙型肝炎的抗病毒治疗寻找一种有效而廉价的药物。方法:患者96例,其中男68例,女28例,平均年龄27.93岁(13～65岁),联苯双酯45.O～67.5mg/d,分3次口服,疗程12个月以上。观察患者的生化反应和病毒学反应。结果:经联苯双酯治疗后患者血清丙氨酸转氨酶(ALT)均迅速降低,1月后ALT恢复正常者72.92％。血清HBeAg阴转率和HBV DNA阴转率均随疗程的延长而逐渐升高,治疗30个月时HBeAg 阴转率达47.5％.HBV DNA阴转率达35.42％。未见明显毒副作用。结论:长期服用联苯双酯不但具有良好的降酶作用,尚具有良好的抗乙肝病毒作用。
Objective: In order to study antiviral efficacy and safety of oral Bifendate for a long term, and to seek for an effective and inexpensive drug for patients with chronic hepatitis B. Methods: Ninety six patients with chronic hepatitis B were enrolled in this study, and every patient was given Bifendate pills (45-67. 5mg/d) at least 12 months. Biochemical response, virological response and side-effect were observated. Results: Biochemical response and virological response of treated patients were obvious. The maximum serum conversion rates of HBeAg, HBeAb and HBV DNA were 47.5%. 25.3%. 35-42%, respectively. No severe side - effect of Bifendate was found. Conclusion: The study shows that oral Bifendate for a long term is an effective and safe therapeutics for patients with chronic hepatitis B. Bifendate not only reduced aminotransferase, but also had antiviral action.
出处
《中西医结合肝病杂志》
CAS
2002年第3期144-144,共1页
Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases
