摘要
目的 探讨转化生长因子 β1(TGF β1)在急性脑梗死发病中的作用及其与脑梗死体积和病情的关系。方法 采用酶联免疫法动态测定 3 9例急性脑梗死患者起病后第 1、3、7天和第14天时血清TGF β1浓度。 结果 TGF β1浓度在起病后第 1、3、7天时显著低于对照组 ,至第 14天则接近对照组水平 ,血清TGF β1与梗死灶大小及临床神经功能缺损评分无显著相关性 ,但与临床预后密切相关。结论 血清TGF β1与脑梗死病理生理过程密切相关 ,对判断急性脑梗死患者预后有一定临床价值。
Objective To investigate serial changes of serum transforming growth factor β1 (TGF β1)and its clinical significance in patients with cerebral infarction.Methods Serum level of TGF β1 was measured by enzyme linked immunosorbent assay(ELISA) at day 1,3,7 and 14 after the onset of cerebral infarction in 39 patients and also in 28 healthy controls.Results The level of serum TGF β1 was significantly decreased at day 1,3 and day 7( P <0.01), to the nadir at day 3, and then tended to return toward the control value at day 14( P >0.05). The nadir of TGF β1 was significantly correlated with progrosis,there was no correlation between circulating TGF β1 and infarction volume or Scandinavian Stroke Scale( SSS).Conclusions TGF β1 may play an important role in the pathophysiology of cerebral infarction, and TGF β1 could be of value in predicting theprogrosis.
出处
《临床内科杂志》
CAS
北大核心
2002年第4期293-294,共2页
Journal of Clinical Internal Medicine
