摘要
目的 :探讨原发性高血压 (EH)与高尿酸血症 (HUA)之间的相互关系。方法 :采用尿酸酶法测血尿酸水平 ,苦味酸法测血清肌酐水平 ,共检测 10 2例EH患者、114例正常人 ,并对比分析。结果 :EH患者的血尿酸水平比正常对照组显著升高 (P <0 .0 1) ,HUA发生率明显增高 (P <0 .0 1)。其中 :Ⅲ级EH患者血尿酸水平较Ⅰ级EH患者显著升高 (P <0 .0 5 ) ,Ⅲ级EH较Ⅱ级EH、Ⅱ级EH较Ⅰ级EH患者血尿酸水平升高 ,但差异无显著性 (P>0 .0 5 )。血尿酸水平与收缩压、舒张压均呈正相关。EH伴HUA者肾功能受损 (轻度 )的发生率较不伴HUA者明显升高 (P <0 .0 5 )。结论 :EH与HUA关系密切 ,临床中若两者并存 。
Objective:To analyze the relationship between essential hypertension(EH)and hyperuricemia(HUA).Methods:The concentration of serum uric acid(SUA)was measured with uricase method and that of serum creatinine(Scr)was measured with carbazotic acid method in 216 cases including 102 EH patients and 114 normal people.Results:The SUA level of EH patients was higher than that of normal people(P<0 01),and the incidence of HUA among EH patients was significantly higher than that of control(P<0 01).Among the EH patients,the SUA level of grade Ⅲ patients was higher than that of gradeⅡ's,and the later was higher than that of gradeⅠ's,although the differences were not statistically significant(P<0 05).There was positive correlations between SUA level and systolice pressure,and between SUA level and diastolic pressure.The increase rate of Scr was higher in EH patients with HUA than that in EH patients without HUA(P<0 05).Conclusion:There might be close relation between EH and HUA,and to lower the serum uric acid is as important as to lower blood pressure in clinical treatment.
出处
《贵阳医学院学报》
CAS
2002年第3期223-224,228,共3页
Journal of Guiyang Medical College
