摘要
目的探讨黏液性肾上腺皮质腺瘤的临床病理特征。方法对1例黏液性肾上腺皮质腺瘤进行临床病理学及免疫组化分析,并进行文献复习。结果患者女,年龄40岁,上腹部、右腰部疼痛不适,增强CT示右侧肾上腺区软组织肿块。肿瘤有一层薄的纤维性包膜,突出的特征为间质内见较多的黏液,黏液内漂浮增生的多边形细胞呈条索状、假腺样、小巢样排列,多边形瘤细胞胞浆中等量,嗜酸性或嗜双色性,核圆,偶见小核仁,间质内纤维增生分隔瘤组织呈小结节状;其间夹杂有经典的肾上腺皮质腺瘤。免疫组化显示:黏液区内瘤细胞及经典的肾上腺皮质腺瘤瘤细胞阳性表达Ckpan、Syn、Inhibin-α、MelanA,不表达CK7、CK20、Villin、SMA、P63、Calponin、S100、CgA。结论黏液性肾上腺皮质腺瘤是一种少见的肿瘤,有独特的形态学表现,间质内黏液及黏液区内瘤细胞的特殊形态学表现,以及免疫组化是正确诊断和鉴别诊断的关键。
Objective To study the clinical and pathological features of myxoid adrenal cortical adenoma. Methods We analyzed the clinicopathologic and immunohistochemical characteristics of 1 case of myxoid adrenal cortical adenoma and reviewed the literatures. Results A-40-year-old woman felt pain on the right waist and had abdominal discomfort. Enhanced CT showed soft tissue mass in the right adrenal gland. The lesion had a thin fibrous capsule. The characteristic feature of the tumor was ample extracellular myxoid material. There were anastomosing cords,pseudoglands and nest like of tumor cells floating loosely in the myxoid background. The tumor cells were polygonal and had moderate amounts of eosinophilic or amphophilic cytoplasm, the nuclei were round to oval with occasionally visible nucleoli. There were conventional adrenal cortical adenoma in some areas. Immunohistochemistry showed that the polygonal cells and the cells of conventional adrenal cortical adenoma were positive expression of CKpan,Inhibin-α, Syn, MelanA and negative expression of CK7, CK20, Villin, SMA, P63, Calponin, S100, CgA. Conclusion Myxoid adrenal cortical adenoma is a rare tumor with unique morphological features. The special morphological features of interstitial myxoid material, polygonal cells floating in the myxoid background and immunohistochemistry are the keys of correctly diagnosis and differential diagnosis.
出处
《中华临床医师杂志（电子版）》
CAS
2014年第11期35-37,共3页
Chinese Journal of Clinicians(Electronic Edition)
