摘要
目的:比较管氏肾病四联疗法与常规西医治疗对慢性肾功能衰竭(CRF)的临床疗效差异。方法:80例患者随机分成观察组和对照组,每组40例。两组均要求低蛋白、低磷饮食,观察组给予管氏肾病四联疗法治疗,包括①选用肾俞、脾俞或肝俞、足三里、关元两组穴位交替行隔肾衰药饼灸;②针刺耳穴肾、交感、肾上腺、肺、皮质下;③采用黄芪注射液混合利多卡因注射液,于肺俞、脾俞、肾俞等穴位行穴位注射;④以肾衰1号为主辨证加减行中药汤剂治疗。对照组给予西医常规方法治疗。治疗6个月后观察两组临床疗效及血肌酐(Scr)、血尿素氮(BUN)、内生肌酐清除率(Ccr)、24h尿蛋白定量等指标的差异。结果:观察组治疗后显效率为50.0%(20/40)、总有效率为82.5%(33/40),分别优于对照组的25.0%(10/40)、45.0%(18/40)(均P<0.05);两组治疗后Scr、BUN、24h尿蛋白定量水平均明显降低(均P<0.05),Ccr明显升高(均P<0.05),观察组治疗后Scr、BUN、24h尿蛋白定量水平较对照组降低更明显(均P<0.05)。结论:管氏肾病四联疗法治疗慢性肾功能衰竭疗效优于常规西药治疗,能够改善肾功能、临床症状及体征,提高患者生活质量。
Objective To compare the differences in the clinical efficacy between Guans quadruple therapy for kidney disease and the conventional western medication in the treatment of chronic renal failure（CRF）.MethodsEighty patients were randomized into an observation group and a control group,40cases in each one.In the observation group,besides the physician instruction of low protein and low phosphorus diet in the two groups,Guan＇s quadruple therapy for kidney disease was applied,including①the isolated herbal moxibustion at Shenshu（BL 23）and Pishu（BL 21）,or Ganshu（BL 18）,Zusanli（ST 36）and Guanyuan（CV 4）alternatively;②acupuncture at the auricular points such as shen（CO10）,jiaogan（AH6）,Shenshangxian（TG2）,fei（CO14）and pizhixia（AT4）;③injection of mixture of astragalus injection and lidocaine injection at Feishu（BL 13）,Pishu（BL 21）,Shenshu（BL 23）and the others;④ modified Shenshuai Yihao decoction according to syndrome differentiation.In the control group,the conventional western medication was used.After 6months of treatment,the differences were observed between the two groups in the clinical efficacy,serum creatinine（Scr）,blood urea nitrogen（BUN）,endogenous creatinine（Ccr）and 24hurine protein quantitation（UPQ）.Results In the observation group,after treatment,the remarkably effective rate was 50.0%（20/40）and the total effective rate was 82.5%（33/40）,which were superior to 25.0%（10/40）and 45.0%（18/40）in the control group（both P〈0.05）.After treatment,the levels of Scr,BUN and 24hUPQ were reduced apparently（all P〈0.05）,and the level of Ccr was increased apparently in the two groups（both P〈0.05）.After treatment,the levels of Scr,BUN and 24hUPQ were reduced much more apparently in the observation group as compared with those in the control group（all P〈0.05）.Conclusion Guan＇s quadruple therapy for kidney disease achieves a better efficacy on CRF compared with the conventional western medication.This therapy improves renal functions,relieves clinical symptoms and physical signs and benefits the life quality of patients.
出处
《中国针灸》
CAS
CSCD
北大核心
2014年第7期641-645,共5页
Chinese Acupuncture & Moxibustion
关键词
慢性肾功能衰竭
针灸
管氏肾病四联疗法
chronic renal failure
acupuncture-moxibustion
Guan＇s quadruple therapy for kidney disease
