摘要
目的总结妊娠期合并鼻咽恶性肿瘤患者的临床资料,探讨妊娠期合并鼻咽恶性肿瘤的临床特点,以达到早期诊断、早期治疗的目的。方法以2007年9月至2012年7月收治的妊娠期合并鼻咽恶性肿瘤5例作为研究对象。其中鼻咽鳞状细胞癌4例,鼻咽恶性肌上皮瘤1例。回顾分析患者的临床表现、诊断结果及治疗情况,并对患者及其子代进行随访。结果 5例患者均为单胎妊娠,3例(60.00%)在妊娠过程中活检确诊后终止妊娠行引产术,2例(40.00%)为妊娠中发病,分别于产后1周和产后1个月活检确诊。新生儿健康存活。鼻咽鳞状细胞癌患者均采用同期放化疗,鼻咽恶性肌上皮瘤患者采用经鼻内镜及软腭联合径路手术治疗,术后1周辅助放疗。结论妊娠期合并鼻咽恶性肿瘤较为少见,合并鼻咽恶性肌上皮瘤更为罕见。妊娠期由于检查及用药的局限性,容易出现漏诊及误诊。治疗应根据肿瘤性质、分期、患者意愿等因素综合考虑,并对患者及子代做长期随访。
Objective To summarize the clinical data of patients with nasopharyngeal carcinoma in pregnancy and to discuss the clinical features.Methods The clinical data of 5 cases of nasopharyngeal carcinoma in pregnancy from September 2007 to July 2012 were retrospectively analyzed.Of them, 4 were with nasopharyngeal squamous cell carci-noma and 1 with nasopharyngeal malignant myoepithelioma.Results All 5 cases were singleton pregnancies, 3 of which （60.00%） terminated the pregnancy and induced abortion after being confirmed as nasopharyngeal carcinoma by biopsy in the pregnancy;2 of which（40.00%） were onsets in pregnancy and confirmed by biopsy in 1 week and 1 month after delivery, and their newborns survives well.The patients with nasopharyngeal squamous cell carcinoma were treated with concomitant chemo-radiotherapy.The one with nasopharyngeal malignant myoepithelioma was treated with endoscopy in combination with the soft palate approach surgery and adjuvant radiotherapy one week after the surgery. Conclusion Nasopharyngeal carcinoma in pregnancy and nasopharyngeal malignant myoepithelioma in pregnancy are rare.Because of the limitation of examination and medication, treatment should be based on the comprehensive consid-eration about the nature and clinical stage of tumor and patient preference.The long-term follow-up is also necessary to the patients and their offspring.
出处
《山东大学耳鼻喉眼学报》
CAS
2014年第3期28-30,共3页
Journal of Otolaryngology and Ophthalmology of Shandong University
关键词
妊娠
鼻咽肿瘤
误诊
治疗
Pregnancy
Nasopharyngeal carcinoma
Erroneous diagnosis
Treatment
