摘要
咪唑啉I2受体是一种非G蛋白偶联受体,其生理功能及临床意义目前尚不十分清楚。近年大量研究表明I2受体通过相关配体介导多种行为学效应。激活咪唑啉I2受体可能产生镇痛、抗抑郁、调节阿片受体功能、神经元保护等多种药理学作用。该文着重介绍了I2受体的分布、细胞定位、分子结构、信号转导、内源性配体和选择性配体及其相关神经药理学效应的研究进展。
Imidazoline-I2 receptor is a group of non-G protein-coupled receptors （GPCR）. Its physiological function and clinical significance remains elusive. Accumulating evidence has implicated the imidazoline-I2 receptors in a wide range of behavioral effects, including analgesia, antidepressant-like effects, modulation ofμopioid receptors and neuroprotection. Here, we provided an updated overview of its location, molecular structure, signal transduction, endogenous ligands, synthetic ligands and related neuropharmacological effects.
出处
《神经药理学报》
2013年第1期48-64,共17页
Acta Neuropharmacologica
基金
美国国立卫生研究院NIH(No.1R01DA034806
No.1R21DA033426)
