摘要
目的观察胸段背根神经节脉冲射频(pulse radio frequency,PRF)刺激联合普瑞巴林治疗带状疱疹后遗神经痛(postherpetic neuralgia,PHN)的临床疗效分析。方法 62例胸部PHN患者随机均分为药物组及联合组,观察并比较两组患者治疗前、后疼痛VAS评分、匹兹堡睡眠质量指数(pittsburgh sleep quality index,PSQI)评分、治疗后曲马多减少量、治疗期间不良反应及远期疗效。结果与治疗前比较,治疗后两组疼痛VAS评分、PSQI评分和治疗后曲马多减少量明显降低;且联合组降低更明显(P<0.05)。与药物组比较,联合组患者治疗期间头晕、嗜睡、共济失调等不良反应发生率明显降低(P<0.05),但有部分患者出现穿刺部位疼痛。与药物组比较,联合组患者疼痛缓解率明显提高,精神面貌和生活质量明显改善,部分患者恢复了劳动或工作能力(P<0.05)。结论胸段背根神经节脉冲射频刺激联合普瑞巴林可有效治疗PHN。
Objective To observe the clinical curative effect of thoracic dorsal root ganglion pulse radio frequency stimulation combined with pregabalin in treatment of postherpetic neuralgia （PHN）.Methods Sixty-two PHN patients were randomly divided into the single drug group and combination group （n=31）.The pre-and post-treatment VAS values and pittsburgh sleep quality in-dex （PSQI）,decreased dosage of tramadol after treatment,adverse reaction during treatment,and long-term therapeutic effects were observed.Results VAS values,PSQI and tramadol dosage de-creased significantly post-treatment in both groups,especially in the combination group （P 〈 0.05）. In addition,the incidence of dizziness,somnolence and ataxia was less,but puncture pain was more in combination group （P 〈 0.05 ）.Long-term therapeutic effects of patients in the combination group were significantly improved.Conclusion Thoracic dorsal root ganglion pulsed radio frequence com-bined with pregabalin is effective in the treatment of PHN.
出处
《临床麻醉学杂志》
CAS
CSCD
北大核心
2014年第7期663-665,共3页
Journal of Clinical Anesthesiology
