摘要
目的:探讨β1β2肾上腺素能受体(β-AR)在针刺调节肠运动中的作用。方法:β1-/-β2-/-组(β1β2受体敲除)和对照组(正常野生型CL57BL/6)小鼠各15只,利用自制水囊测压头监测空肠内压,显示空肠运动情况,待压力稳定分别电针天枢、大肠俞两穴各2 min(15 Hz,2 mA)。观察并记录针刺前后空肠运动并分析数值变化。结果:β1-/-β2-/-组电针前后肠内压无明显变化;正常野生组小鼠天枢、大肠俞穴电针后肠内压值有极显著变化(P<0.01)。两组小鼠的腧穴效应方向基本一致。结论:针刺对肠运动的调节机制是多方面的,其中,β受体为介导电针调节空肠运动的关键因素之一。
Objective ：To investigate the β1β2 -adrenergic receptor （β- AR） in acupuncture regulating bowel movement in rats. Methods： β1-/-β2-/-group （β1β2 receptor knockout） and control group （normal wildtype CI.57BL/6） mice,15 in each, were monitored jejunum pressure by using homemade bladders pressure. The jejunum sports were detected and when the pressure was stable,Tianshu and Dachangshu were needled respectively for 2 minutes （ 15 Hz,2mA）. We observed and recorded the jejunum motion waveform before and after acupuncture and analyzed the numerical changes. Results：β1-/-β2-/- intestinal pressure before and after electro -acupuncture had no significant change. Normal wild mice＇ s intestinal pressure had a very significant change after EA （ P 〈 0.01 ）. Two groups＇ acupoints effects were consistent with the direction. Conclusion：The effect of acupuncture for bowel movement adjustment is multifaceted,including β receptor mediating electroacupuncture regulating movement is one of the key factors.
出处
《中华中医药学刊》
CAS
2014年第8期1825-1826,I0001,共3页
Chinese Archives of Traditional Chinese Medicine
基金
国家自然科学基金项目(81202744
81373749)
国家重点基础研究发展计划(973计划)项目(2011 CB 505206)
中国中医科学院自主选题项目(ZZKF 06003)
江苏省高校自然科学研究计划项目(11 KJB 360008)
江苏省特色优势学科
江苏省高校青蓝工程优秀科技创新团队项目
关键词
β1β2受体
空肠
电针
β1β2 receptor
j ej unum
electroacupuncture
