摘要
目的比较SOX方案与FOLFOX4方案治疗晚期胃癌的临床疗效和毒副反应。方法 51例晚期胃癌患者随机分为2组。SOX方案组27例接受替吉奥+奥沙利铂治疗,而FOLFOX4方案组24例接受氟尿嘧啶+亚叶酸钙+奥沙利铂治疗。结果 51例患者均可评价疗效,SOX方案组有效率48.1%,中位疾病进展时间6.0个月,中位生存时间10.3个月;FOLFOX4方案组分别为45.8%、5.8个月、10.0个月,2组比较差异无统计学意义(P>0.05)。SOX方案组Ⅲ、Ⅳ度恶心呕吐发生率低于FOLFOX4方案组(P<0.05)。结论SOX与FOLFOX4 2种方案治疗晚期胃癌疗效相似,但前者的毒副反应更轻。
Objective To compare the efficacy and toxicities of SOX and FOLFOX4 regimen in the treatment of advanced gastric cancer. Methods Fifty patients with advanced gastric cancer were divided into two groups,27 patients of the SOX group received S-1 ＋ oxaliplatin,and 24 patients of the FOLOX4 group received 5-Fu ＋ calcium folinate＋ oxaliplatin. Results The overall response rate,median time to progression and median survival time were 48. 1%,6. 0 months and 10. 3 months,respectively; and were 45. 8%,5. 8 months and 10. 0 months（ P 〉 0. 05）. The incidence of Ⅲ and Ⅳ nausea and vomiting in the SOX group was lower than that of the FOLFOX4 group（ P〈 0. 05）.Conclusion SOX and FOLFOX4 regimen has the similar efficacy,and can be tolerated,but the SOX regimen is safer.
出处
《肿瘤基础与临床》
2014年第4期288-290,共3页
journal of basic and clinical oncology
关键词
替吉奥
奥沙利铂
氟尿嘧啶
亚叶酸钙
晚期胃癌
S-1
oxaliplatin
fluorouracil
calcium folinate
advanced gastric cancer
