摘要
丹参酮类是从传统中药丹参(Salvia miltiorrhiza Bunge)及其同属植物中分离到的一大类脂溶性天然产物,包括丹参酮ⅡA、隐丹参酮、丹参酮Ⅰ、二氢丹参酮Ⅰ等多种成分。丹参酮类与丹酚酸类均被证实是丹参的主要特征性成分和活性成分,具有较明显的心脑血管保护活性。近年来研究发现,丹参酮类在体内外有较好的抗肿瘤活性。该文就丹参酮类化合物尤其是丹参酮ⅡA的抗肿瘤作用与机制的最新研究进展作一综述,以期为该类化合物的研究和开发提供参考。
Tanshinones are a large class of hydrophobic natural products isolated from traditional Chinese herb Salvia miltiorrhiza Bunge and related plants. Tanshinones include tanshinone ⅡA, cryptotanshinone, tanshinone I, dihydrotanshinone, and so on. Both the tanshinones and the salvianolic acids have been identi-fied as the characteristic and main active ingredients of Salvia miltiorrhiza Bunge with cardiovascular protective activities. Ac-cumulated data in recent years have revealed that tanshinones possess remarkable anti-cancer activities both in vivo and in vitro. In this review, we summarize the latest progress of the an-ti-cancer effect and the underlying mechanisms of tanshinones, particularly with emphasis on tanshinone ⅡA, which might pro-vide reference for the further research and development of these compounds.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2014年第8期1041-1044,共4页
Chinese Pharmacological Bulletin
基金
澳门科学技术发展基金(No 021/2012/A1)
澳门大学研究基金(No MRG007/CXP/2013/ICMS,MRG008/CXP/2013/ICMS)
关键词
隐丹参酮
肿瘤
作用与机制
进展
tanshinone ⅡA
cryptotanshinone
tanshinone I
dihydrotanshinone I
cancer
effect and mechanisms
progress
