摘要
目的:探讨不明原因习惯性流产(UHA)患者体内绒毛共刺激分子B7-1和B7-2的表达情况。方法:分别选取35例UHA患者作为病例组,50例正常妊娠组和50例正常未妊娠组,采用EpicsXLII型流式细胞仪记录单核细胞中的B7-1和B7-2阳性细胞百分比。结果:3组的B7-1水平差异有统计学意义(F=23.725,P=0.000),病例组高于正常妊娠组和正常未孕组(P<0.05);3组的B7-2水平差异有统计学意义(F=19.807,P=0.001),病例组低于其他两组(P<0.05);相关性分析:B7-1与不明原因习惯性流产疾病呈正相关关系,r=0.832(t=5.632,P=0.012);B7-2与不明原因习惯性流产疾病呈负相关,r=-0.745(t=6.032,P=0.009)。结论:不明原因习惯性流产患者体内B7-1较高,B7-2较低,通过选择性的减弱B7-1水平,增强B7-2水平或可改善不明原因习惯性流产患者病情。
To study the expression of B7-1 and B7-2 in patients with unexplained habitual abortion.Methods：35 UHA patients were selected as case group,and 50 normal pregnancy women as normal preg-nancy group and 50 normal unpregnancy women as normal unpregnancy group.The Epics-XLII flow cytometry was used to record the percentage of positive cells of B7-2 and B7-1 .Results：Difference of B7-1 level in the three groups was statistically significant （F=23.725,P=0.000）,the case group was higher than normal pregnancy group and normal unpregnancy group （P〈0.05）;difference of B7-2 level in the three groups was statistically sig-nificant （F=19.807,P=0.001）,the case group was lower than the other two groups （P〈0.05）;Correlation a-nalysis,B7-1 were positively correlated with unexplained habitual abortion,r=0.832 （t=5.632,P=0.012）,＆amp;nbsp;B7 -2 was negatively correlated with unexplained habitual abortion,r =-0.745 （t =6.032,P =0.009 ）. Conclusion：B7-1 in patients with unexplained habitual abortion is higher,while B7-2 is low.By decreasing B7-1 level and increasing the B7-2 levels,we can effectively improve the state of unexplained habitual abortion.
出处
《中国性科学》
2014年第8期8-10,共3页
Chinese Journal of Human Sexuality
