摘要
目的:研究以白花蛇舌草为主方剂配合放疗治疗食道癌的临床疗效,从而更好地指导食道癌的治疗。方法:80例食道癌患者随机分为对照组(放射性治疗)和观察组(白花蛇舌草方剂联合放疗),观察两组患者治疗后的临床疗效、生活质量、不良反应发生情况,以及治疗后肿瘤坏死因子-β(TNF-β)、超敏C反应蛋白(hs-CRP)水平,以及血清肿瘤标志物CA125,CEA变化情况。结果:与对照组相比,观察组治疗的总有效率明显升高(60.0%vs 42.5%),治疗后生活质量明显改善(80.0%vs 62.5%),P<0.05。治疗期间,两组不良反应比较,差异没有统计学意义。与对照组相比,观察组治疗后TNF-β,hs-CRP水平均明显降低,P<0.05;而两组CA125,CEA水平比较没有统计学意义。结论:以白花蛇舌草为主方剂配合放疗治疗食道癌效果显著,能有效改善患者的生活质量,延长患者的两年生存率,且不良反应少,值得临床推广使用。
Objective： To study clinical efficacy of Herba Hedyotidis Diffusae as major prescription combining the radiotherapy in treating esophageal cancer for the guidance of the better treatment. Method： Eighty patients with esophageal in our hospital during the period from Jan 2010 to Jan 2013 were randomized into the control group（radiotherapy） and the observation group（Herba Hedyotidis Diffusae combined with radiotherapy）.The clinical efficacy,life quality and the occurrence of adverse reaction of patients in two groups after treatment,and the tumor necrosis factor-β（TNF-β）,high sensitive C creactive protein（hs-CRP）,serum tumor markers such as CA125 and CEA in the two groups were observed. Result： Compared with the control group,the total effective rate was significantly increased（60. 0% vs 42. 5%） and the life quality was obviously impoved（80. 0% vs62. 5%） in the observation group after treatment,P〈0. 05. The comparison of adverse reactions during the treatment period between the two groups was not statistical difference. Compared with the control group,the levels of TNF-β and hs-CRP were significantly reduced（P〈0. 05）,the comparison of CA125 and CEA levles were not statistical difference. Conclusion： The prescription mainly consisting of Herba Hedyotidis Diffusae as major prescription combining with the chemotherapy in treating esophageal cancer delivers significant effect,and it can effectively improve the life quality of patients,extend two-year survival rate of patient,and less adverse reactions are found,being worthy of clinical promotion.
出处
《中国实验方剂学杂志》
CAS
北大核心
2014年第17期209-211,共3页
Chinese Journal of Experimental Traditional Medical Formulae
关键词
白花蛇舌草
放疗
食道癌
Herba Hedyotidis Diffusae
radiotherapy
esophageal cancer
