期刊文献+

2050例孕中期母血产前筛查结果分析

原文传递
导出
摘要 目的:探讨孕中期母血产前筛查对胎儿染色体异常和神经管畸形的临床价值。方法:应用酶联免疫法检测孕中期孕妇血中AFP、HCG-b的浓度,结合孕周、年龄、体重等因素,通过计算机软件计算风险率,对高风险孕妇进行羊水细胞染色体核型分析和B超确诊。结果:2 050位孕妇中筛查出唐氏综合征高风险45例,占2.1%,确诊10例。18-三体综合征36例,占1.7%,确诊4例。神经管畸形筛查高危17例,占0.8%,确诊3例。结论:孕中期产前筛查结合产前诊断,是减少先天性缺陷患儿出生的有效方法。
作者 孙宏雁
出处 《中国农村卫生事业管理》 2014年第8期993-994,共2页 Chinese Rural Health Service Administration
  • 相关文献

参考文献8

二级参考文献34

  • 1江苏省计划生育委员会出生缺陷干预项目组.中位倍数法及其在产前筛查中的应用[J].中华妇产科杂志,2004,39(6):428-429. 被引量:18
  • 2卓乐雯,廖灿,宋淑本,涂新枝.唐氏综合征产前筛查研究[J].中国实用妇科与产科杂志,2004,20(7):414-416. 被引量:48
  • 3肖坤则,李守柔.中国围产儿素质现状的调查研究[J].中华医学杂志,1989,69(4):185-188. 被引量:32
  • 4Wald NJ, Cuckle H, Brock JH, et al. Maternal serum-alpha-fetoprotein measurement in antenatal screening for anencephaly and spina bifida in early pregnancy. Report of U.K. collaborative study on alpha-fetoprotein in relation to neural-tube defects. Lancet
  • 5Macri JN , Kasturi RV, Krantz DA, et al. Maternal serum alpha-fetoprotein (MSAFP) patient-specific risk reporting: its use and misuse. Am J Hum Genet,1990,46:587-590.
  • 6Palomaki GE, Neveux LM. Using multiples of the median to normalize serum protein measurements. Clin Chem Lab Med, 2001,39:1137-1145.
  • 7Kutteh WH, Wester R, Kutteh CC. Multiples of the median: an alternative method for reporting antiphospholipid antibodies in women with recurrent pregnancy loss.Obstet Gynecol, 1994,84:811-815.
  • 8Parvin CA, Gray DL, Kessler G. Influence of assay method differences on multiple of the median distributions: maternal serum alpha-fetoprotein as an example. Clin Chem, 1991,37:637-642.
  • 9Cuckle HS, Wald NJ, Thompson SG. Estimating a woman′s risk of having a pregnancy associated with Down′s syndrome using her age and serum alpha-fetoprotein level. Br J Obstet Gynaecol, 1987,94:387-402.
  • 10Onda T, Kitagawa M, Takeda O, et al. Triple marker screening in native Japanese women. Prenat Diagn,1996,16:713-717.

共引文献160

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部