摘要
宫颈癌是仅次于乳腺癌的第二位常见女性恶性肿瘤,严重威胁妇女生命。近几年国内外报道宫颈癌发病率及病死率均明显下降,但有年轻化的倾向,35岁以下的妇女宫颈癌发病率明显上升。目前公认宫颈癌发病的根本病因与人乳头瘤病毒(HPV)感染相关,HPV感染后绝大多数的宿主免疫系统可以将病毒清除,当机体免疫系统功能下调,宫颈上皮细胞因受HPV感染不能有效清除病毒,最终导致宫颈癌发生。病毒感染后通过多种机制逃脱免疫识别。高迁移率族蛋白B1(HMGB1)在诱导宿主免疫抑制过程中起到重要作用,在蛋白表达水平上为宫颈鳞癌相关蛋白,但由HPV感染所致慢性炎症进展为宫颈癌这一过程中HMGB1是否发挥作用及其具体作用机制仍不清楚。因此,了解宫颈癌中宿主免疫系统的改变对于诊断、治疗及肿瘤的防治有着重要的意义。综述HMGB1与宫颈癌免疫之间的相关性。
Cervical cancer is second only to breast cancer was the most common female malignant tumor, a serious threat to women′s lives. Reported at home and abroad in recent years, cervical cancer incidence and mortality were significantly decreased, but there was a tendency of younger under 35 cervical cancer incidence rate rose significantly. Cervical cancer, the fundamental cause of the disease is recognized as with human papilloma virus （human papillomavirus, HPV） infection related,after the HPV infection most of the host immune system can clear the virus, when the body′s immune system dysfunction, cervical epithelial cells due to HPV infections cannot be effectively remove viruses, eventually lead to cervical cancer. After virus infection through a variety of mechanisms to escape immune recognition. High mobility group protein 1 （high mobility group box 1 protein, HMGB1） play an important role in the process of induction of host immune suppression, the protein expression level of cervical squamous carcinoma related proteins. But chronic inflammation caused by HPV infection progression to cervical cancer whether HMGB1 play a role in this process, the specific mechanism remains unclear. Therefore, understand the change of the host immune system for cervical cancer diagnosis, treatment and prevention will be of great significance. This will be for HMGB1 and reviews the correlation between cervical cancer immune.
出处
《国际妇产科学杂志》
CAS
2014年第4期386-389,共4页
Journal of International Obstetrics and Gynecology
基金
国家自然科学基金(30973191)
国家自然基金青年项目(81202048)
高等学校博士学科点专项科研基金(20122104120012)
辽宁省科学技术计划项目(2011225009)
辽宁省医学高峰建设工程(2010696)
沈阳市社会发展科技攻关专项(F11-262-9-15)
"盛京自由研究者"计划(200806)
关键词
宫颈肿瘤
癌
宫颈上皮内瘤样病变
乳头状瘤病毒科
高迁移率族蛋白质类
Uterine cervical neoplasms
Carcinoma
Cervical intraepithelial neoplasia
Papillomaviridae
High mobility group proteins
