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盐酸美金刚治疗68例老年帕金森病痴呆患者的临床疗效分析 被引量:14

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摘要 目的:对盐酸美金刚治疗老年帕金森病痴呆患者的临床疗效进行分析。方法:资料随机选取收治的老年帕金森病痴呆患者68例,分为两组,给予对照组常规治疗,研究组患者在对照组治疗基础上加用盐酸美金刚进行治疗,并对两组临床资料进行回顾性分析。结果:治疗第4周、16周后,对照组MMSE、MoCA评分情况,明显优于治疗前;且研究组MMSE、MoCA评分情况,明显优于治疗前及对照组,两组比较,差异具有统计学意义(P<0.05);研究组日常生活完成有效率90.63%;明显高于对照组78.13%;两组比较,差异具有统计学意义(P<0.05)。结论:盐酸美金刚治疗老年帕金森病痴呆的疗效较为显著,值得在临床中推广应用。
作者 程玉惠
出处 《吉林医学》 CAS 2014年第22期4956-4957,共2页 Jilin Medical Journal
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  • 1于兑声,恽晓平.运动疗法与作业疗法[M].北京:华夏出版社,2002:472-474,480-481.
  • 2Aaraland D,Andersen K,Larsen JP,et al. Prevalence and characteristicsof dementia in Parkinson disease : an 8 -year prospective study [ J〕. ArchNeural,2003;60(3) :387-92.
  • 3American Psychiatric Association. Diagnostic and statistical manual ofmental disorders DSM-IV [ M] . Washington DC: American PsychiatricAssociation, 2000 ; 78.
  • 4McKeith I,Mintzer J, Aarsland ,et al. Dementia with Lewy bodies〔 J〕.Lancet Neurol,2004;3(1): 19-28.
  • 5Farlow MR, Graham SM, Alva G. Memantine for the treatment of Alzhei-mere disease : tolerability and safety data from clinical trials (J ]. DrugSafety,2008;31(7) :577.
  • 6Sonkusare SK, Kanl CL, Ramarao P. Dementia of Alzherimerc' s diseaseand other neurodegenerative disorders-memantine,a new hope〔 J〕. Phar-macol Res,2005;51(l) :4-71.
  • 7Varanese S, Howard J, Dirocco A. NMD A antagonist memantine improveslevodopa-induced dyskinesis and“ on-off” phenomena in Parkinson^ dis-ease [J}. Movement Disorders,2010;25 (4) :508.
  • 8Aaraland D,Andersen K,Larsen JP. Prevalence and characteristicsof dementia in Parkinson disease:an 8-year prospective study[J].Archives of Neurology,2003.387-392.
  • 9Mckeith I,Mintxer J,Aaraland D. Dementia with lewy bodies[J].Lancet Neurology,2004.19-28.
  • 10American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders DSM-IV[M].Washington,DC:American Psychiatric Association,2000.78.

同被引文献54

  • 1李玉梅,刘琨,王婷,朱友德.不同类型帕金森病患者的记忆障碍及相关因素[J].中国行为医学科学,2005,14(9):812-813. 被引量:10
  • 2Begatta V, Sgobio C, Pendolino V, et al. Rebalance of striatal NMDA/AMPA receptor ratio underlies the reduced emergence of dyskinesia during I)2 -like dopamine agonist treatment in experi- mental Parkinson "s disease [ J ]. J Neurosci, 2012, 32 (49) : 17921 - 17931.
  • 3Leroi I, Atkinson R, Overshott R. Memantine improves goal at- tainment and reduces caregiver burden in Parkinson's disease with dementia [ J ]. Int J Geriatr Psychiatry, 2014,29 (9) :899 - 905.
  • 4Ondo WG, Shinawi L, Davidson A, et al. Memantine for non - motor features of Parkinson's disease: a double -blind placebo controlled exploratory pilot trial [ J]. Parkinsonism Relat Disord, 2011,17(3) :156 - 159.
  • 5Aars[and D, Ballard C, Walker Z, et al. Memantine in patients with Parkinson's disease dementia or dementia with Lewy bodies: a double - blind, placebo - controlled, multicentre trial [ J ]. Lancet Neurol, 2009,8 (7) :613 - 618.
  • 6Merello M, Nouzeilles MI, Cammarota A, et al. Effect of me- mantine (NMDA antagonist) on Parkinson's disease: a double - blind crossover randomized study [ J ]. Clin Neuropharmacol, 1999,22 (5) :273 - 276.
  • 7Truong DD, Bhidayasiri R, Wolters E. Management of non - mo- tor symptoms in advanced Parkinson's disease [ J]. J Neurol Sci, 2008,266( 1 -2) :216 -228.
  • 8Rodrigues de Paula F, Teixeira - Salmela LF, Coelho de Morals Faria CD, et al. Impact of an exercise program on physical, emo- tional, and social aspects of quality of lit of individuals with Par- kinson's disease [ J ]. Mov Disord, 2006,21 ( 8 ) .. 1073 - 1077.
  • 9Sonkusare SK, Kanl CL, Ramarao P. Dementia of Alzherimer's disease and other neurodegenerative disorders - memantine, a new hope [J]. Pharmaeol Res, 2005,51 ( 1 ) :1 - 17.
  • 10Areosa SA, Sherriff F, MeShane R. Memantine for dementia [ J]. Coehrane Database Syst Rev, 2005,20 (3) : CD003154.

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