摘要
目的应用文献研究方法探讨谷胱甘肽硫转移酶M1(glutathione S transferase M1,GSTM1)基因多态性与喉癌易感性的关系。方法全面检索ISI Web of KnoWledge、Pubmed、Embase和中国期刊全文数据库等数据库,按照纳入和排除标准纳入文献,提取数据资料进行综合定量研究,并按照种族类别和对照来源进行亚组分析。结果最终纳入22篇文献,包含2535例喉癌患者和3233例对照样本。Meta分析显示,GSTMI空白基因型与喉癌易感性有统计学关联(OR=1.30,95%CI:1.07~1.57)。种族类别亚组分析显示GSTMl空白基因型与喉癌易感性在亚洲人群中有统计学关联(OR=1.68,95%6CI:1.03~2.76),但在高加索人群中则否(OR=1.13,95%CI:1.00~1.29);按对照来源行亚组分析,提示以社区为基础的病例对照研究(OR=1.15,95%CI:1.01l^1.31)和以医院为基础的同类研究(OR=1.81,95%CI:1.13~2.89)均显示这样的统计学关联性。结论GSTMl基因多态性是喉癌发生的危险因素,并与人群种族类别有关。
Objective To investigate the possible association of glutathione s-transferase M1 （GSTM1） gene polymorphism with laryngeal cancer susceptibility. Methods An overall literature review was carried out to search relevant papers through searching the nets of PubMed, Embase, ISI Web of Knowledge and Chinese National Knowledge Infrastructure, to select publications on the basis of established inclusion and exclusion criteria. Then, collected data were undergone a comprehensive quantitative analysis through a meta-analysis, combined also a sub-grouping study based on case’s ethnicity and controlling source of the cases. Results Twenty-two trials were included in the present view, including 2535 laryngeal cancer cases and 3233 controls. As shown from this met-analysis, GSTM1 null genotype was significantly associated with increased susceptibility of laryngeal cancer （OR=1.30, 95% CI： 1.07～1.57）. When a stratifying study was made on the basis of race in this group of cases, GSTM1 null genotype exhibited an increased laryngeal cancer susceptibility in Asians （OR=1.68,95% CI：1.03～2.76）, while no significant association was detected in Caucasians （OR=1.13, 95% CI： 1.00～1.29）. When made a subgroup stratifying study in the same way based on the source of controls, significant association could be observed in either the population-based studies （OR=1.15, 95% CI： 1.01～1.31） or the hospital-based ones （OR=1.81, 95% CI：1.13～2.89）. Conclusions This view, based on a meta-analysis, supports the known conclusion that GSTM1 gene polymorphism may associate with significantly increased laryngeal cancer susceptibility, particularly in Asians.
出处
《中国中西医结合耳鼻咽喉科杂志》
2014年第4期252-257,共6页
Chinese Journal of Otorhinolaryngology in Integrative Medicine
基金
上海交通大学医工交叉基金资助项目(YG2011MS26)
