B细胞在Graves’病中的作用被引量：3

The role of B cells in Graves＇ disease

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摘要 Graves’病（GD）是一种B细胞介导、T细胞依赖的器官特异性自身免疫性疾病.其致病性抗体促甲状腺激素受体抗体（TRAb）能导致甲状腺素分泌增加,促进甲状腺增生.以往Graves’病研究认为,B细胞主要通过分泌致病性抗体发挥作用,但是新近研究结果提示,B细胞在疾病中具有更广泛的作用,如抗原提呈、分泌细胞因子等.因此,进一步阐明B细胞在Graves’病中的作用将为Graves’病治疗提供重要的理论基础. Graves＇ disease（GD） is a B cell-mediated and T cell-dependent autoimmune disease. GD is characterized by the over-production of thyroid hormones and thyroid enlargement by agonistic anti-thyrotro- phin receptor autoantibody（ TRAb）. In addition to secrete pathogenic antibody in GD, B cells have recently been implicated to play important roles in antigen presentation, cytokine production and so on. Therfore, the study of B cell function will provide basis for the treatment of GD.

作者蒋学超储以微

机构地区复旦大学基础医学院免疫学系

出处《国际免疫学杂志》 CAS 2014年第5期367-370,共4页 International Journal of Immunology

基金国家自然科学基金（81273215）

关键词 B细胞 Graves’病自身抗体利妥昔单抗 B cells Graves＇ Disease autoantibody Rituximab

分类号 R581.1 [医药卫生—内分泌]

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参考文献29

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