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拉米夫定联合TACE治疗对乙型肝炎相关肝癌患者生存质量和预后的影响 被引量:4

Lamivudine combined with TACE treatment improves the quality of life in patients with HBV-related primary liver cancer
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摘要 目的探讨拉米夫定联合肝动脉化疗栓塞术(TACE)治疗对乙型肝炎相关肝癌患者生存质量的影响。方法 65例HBV DNA阳性原发性肝癌患者按就诊顺序随机分为两组,35例观察组患者在行TACE术后常规给予拉米夫定治疗,30例对照组仅行TACE术。两组患者均在术后4 w应用SF-36量表进行生存质量问卷,术后24 w和48 w随访患者生存情况。结果在术后4 w,观察组和对照组患者躯体健康评分分别为[(75.4±14.3)和(63.8±10.3),P<0.01],躯体角色功能分别为[(69.8±15.2)和(44.0±16.7),P<0.01],躯体疼痛[(63.4±16.5)和(60.6±13.5),P>0.05],心理健康[(63.1±8.7)和(54.1±7.3),P>0.05],精力[(60.8±8.1)和(54.5±7.4),P>0.05],社会功能[(79.5±12.4)和(62.1±9.3),P<0.01],情绪角色功能[(65.2±9.7)和(50.0±8.6),P<0.01],总体健康[(64.8±8.6)和(51.5±7.8),P<0.01];观察组24 w生存率与对照组比较无显著性差异(88.6%对73.3%P>0.05),观察组48 w生存率显著高于对照组(74.3%对50%,P<0.05)。结论拉米夫定联合TACE治疗有利于改善肝癌患者近期部分生存质量,提高患者1 a生存率。
出处 《实用肝脏病杂志》 CAS 2014年第5期539-540,共2页 Journal of Practical Hepatology
关键词 原发性肝癌 拉米夫定 肝动脉化疗栓塞术 生存质量 Primary liver cancer Lamivudine Transcatheter arterial chemoembolization Quality of life
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  • 1Chen CJ, Yang HI, Su J, et al. Risk of hepatocellular carcinoma acrossa biological gradient of serum hepatitis B virus DNA level[j]. JAMA,2006,295(1):65-73.
  • 2Zhou JY, Zhang L, Li L, et al. High hepatitis B virus load is associatedwith hepatocellular carcinomas development in Chinese chronichepatitis B patients: a case control study[j]. Virol J, 2012, 9(16): 1-5.
  • 3Yu SJ, Lee JH, Jang ES, et al. Hepatocellular carcinoma: high hepatitisB viral load and mortality in patients treated with transarterialchemoembolization[j]. Radiology, 2013,267(2):638-647.
  • 4Chen CJ, Yang Hllloeje UH. Hepatitis B virus DNA levels andoutcomes in chronic hepatitis B[j]. Hepatology, 2009,49(5):S72-84.
  • 5Goto T, Yoshida H, Tateishi R, et al. Influence of serum HBV DNAload on recurrence of hepatocellular carcinoma after treatment withpercutaneous radiofrequency ablation[J]. Hepatol Int, 2011,5(3):767-773.
  • 6Yin JH, Li N, Han YF, et al. Effect of antiviral treatment withnucleotide/nucleoside analogs on postoperative prognosis of hepatitisB virus-related hepatocellular carcinoma: a two-stage longitudinalclinical study[J].J Clin Oncol, 2013,31(29):3647-3655.
  • 7Chan ACY, Chok KSH, Yuen WK, et al. Impact of Antiviral Therapy onthe Survival of Patients After Major Hepatectomy for Hepatitis B Virus-Related Hepatocellular Carcinoma [J]. Arch Surg, 2011, 146(6):675-681.
  • 8Wong JS, Wong GL, Tsoi KK, et al. Meta-analysis: the efficacy of anti-viral therapy in prevention of recurrence after curative treatment ofchronic hepatitis B-related hepatocellular carcinoma[j]. AlimentPharmacol Ther, 2011,33(10):1104-1112.
  • 9Koda M, Nagahara T, Matono T, et al. Nucleotide Analogs for Patientswith HBV-Related Hepatocellular Carcinoma Increase the SurvivalRate through Improved Liver Function[j]. Intern Med, 2009,48(1):11-17.
  • 10Xu XJ, Huang PX, Tian H, et al. Role of lamivudine with transarterialchemoembolization in the survival of patients with hepatocellularcarcinoma [j]. Gastroenterol Hepatol, 2014, 29(6):1273-1278.

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