摘要
目的通过研究子痫前期孕妇及正常孕妇外周血中抵抗素与瘦素的含量及相关性,探讨其在子痫前期发病中的作用,评价其诊断价值。方法选择20例子痫前期孕妇为病例组,另选20例正常孕妇为对照组,采用酶联免疫吸附试验(ELISA)检测孕妇外周血中抵抗素及瘦素水平,ROC曲线分析其与子痫前期发病的相关性。结果 1病例组孕妇血清瘦素值较对照组明显升高(P<0.05);2血清瘦素、抵抗素水平与子痫前期发病密切相关。结论血清抵抗素、瘦素水平升高与子痫前期发病有关。抵抗素>22.25μg/L时,灵敏度为80%,特异度为85%;瘦素>17.05μg/L时,灵敏度为80%,特异度为80%;二者联合监测能更好地预测子痫前期发病。
Objective To assess serum resistin and leptin levels as a marker for preeclampsia （PE） and to explore the possibility of AECA and leptin being a marker of severity of preeclampsia. Method Comparative prospective study was conducted among two groups （control and study group） according to the absence or presence of clinical parameters of preeclampsia. Serum resistin and Leptin was determined using ELISA method. Result Serum resistin and leptin was significantly higher in preeclampsia （P 〈 0.05）. Conclusion Resistin and leptin levels were found to be significantly higher among all preeclampsia patients when compared to the control group; serum resistin and leptin in preeclampsia in the correlation suggesting that mechanisms between them, ROC curve analysis has shown that a cut offvahie serum resistin 〉 22.25 μg/L and serum leptin 〉 17.05 μg/L can be used to detect presence of preeclampsia.
出处
《中国医学前沿杂志（电子版）》
2014年第8期55-57,共3页
Chinese Journal of the Frontiers of Medical Science(Electronic Version)
