摘要
以化学交联的聚烯丙基胺盐酸盐拟葡聚糖微凝胶和透明质酸为构筑基元,在导尿管表面层层组装构筑了厚度小于500 nm可控释放抗菌药物的聚合物微凝胶膜。广谱抗菌药物头孢曲松钠通过扩散吸附的方法在2 min内快速负载到聚合物微凝胶膜中,并且在生理盐水中可控释放时间达3 h。抗菌实验表明,组装有层层组装微凝胶膜并负载广谱抗菌药物的导尿管具有令人满意的抗菌效果,避免感染的发生。
The prevention of hospital-acquired infection attributable to indwelling urethral catheter use has recently received increased attention. For controlled release of antibacterial drugs, antibacterial films with a thickness less than 500 nm on urethral catheter were directly constructed by layer-by-layer deposition of poly （ allylamine hydrochloride ） and dextran （ PAH-D ） microgels with hyaluronic acid （ HA ）. PAH-D/HA multilayer films can load negatively charged antibacterial drugs such as ceflriaxone sodium （CTX） in 2 min based on electrostatic interaction between PAH-D microgels and CTX molecules and then release them in 3 h in physiological saline. Direct deposition of microgel films and incorporation of CTX endow the muhilayer micro films with an effective antibacterial performance.
出处
《应用化学》
CAS
CSCD
北大核心
2014年第10期1149-1155,共7页
Chinese Journal of Applied Chemistry
关键词
层层组装
抗菌
微凝胶
导尿管
layer-by-layer assembly, antibacterial, mierogel, urethral catheter
