摘要
将多肽链环化,进行构象限定,是改善肽的生物稳定性和生理活性的重要途径之一。近年来,以环肽为模型研究生物大分子和金属离子相互作用,模拟生物分子对金属离子的特异选择性逐渐引起人们的关注。本文从金属离子的不同类型出发,介绍了环肽对碱金属和碱土金属、过渡金属(Cu,Zn和Ni)、重金属、镧系金属离子识别作用的研究进展;重点讨论了环肽的环化结构对金属离子亲合力和选择性的影响;并简要评述了环肽识别作用研究所面临的挑战和运用前景。
The conformational variability of linear peptides affects the strength and selectivity of receptor binding. In contrast, cyclopeptides adopt more rigid and conformationally constrained structures than their linear analogues, as the cyclization could lead to a restricted mobility of the peptide skeleton. Therefore, the cyclization is one of the important ways to improve the biological stability and physiological activity of the peptides. Furthermore, cyclopeptides are important building blocks in molecular material chemistry and life science, working in diverse areas such as physiological processes, nanoscale materials, and supramolecular chemistry. They are used to study the physiological process, construct transmembrane nanotube channels in order to transport molecules and ions, recognize molecules, anions, and cations. In recent years, the researchers pay more attention to the interaction of biological molecules and metal ions, especially with cyclopeptides as the models. In this paper, we review the research progress of the metal ion recognition functions of cyclopeptides. Alkali and alkaline earth metals, transition metals （such as Cu, Zn and Ni）, heavy metals, and lanthanides are discussed. A major focus has been on the influencing factors to the metal ion affinity and selectivity. The challenges and prospects of the metal ion recognition are also discussed concisely.
出处
《化学进展》
SCIE
CAS
CSCD
北大核心
2014年第9期1537-1550,共14页
Progress in Chemistry
基金
国家自然科学基金项目(No.91326110)
中国工程物理研究院学科909项目资助~~
关键词
环肽
金属离子
络合
传感器
荧光探针
cyclopeptides
metal ions
complexation
sensors
fluorescent probes
