摘要
目的探讨右美托咪定对老年患者全麻诱导过程中心率变异性(HRV)的影响。方法选择全麻老年患者50例,随机均分为两组:D组麻醉诱导前给予右美托咪定负荷量0.5μg/kg稀释至20ml泵注,10min输注完毕,再以0.3μg·kg-1·h-1泵注至插管后5min。C组静脉泵注等量生理盐水。记录入室后(T0)、右美托咪定负荷量结束后(T1)、气管插管前(T2)及插管后1min(T3)、3min(T4)、5min(T5)时HRV指标:总频(TP)、低频(LF)、高频(HF)及低频/高频(LF/HF)。结果与T1时比较,D组T3～T5时LF,T4、T5时HF,T5时TP明显升高(P<0.05);T3～T5时LF/HF明显降低(P<0.05)。与C组比较,T3～T5时D组LF,T2～T5的HF和TP明显升高(P<0.05),T1～T5时D组LF/HF明显降低(P<0.05)。结论全麻诱导过程中给予右美托咪定能够升高HRV,可以有效地调节交感-迷走神经张力的均衡性,稳定心血管功能。
Objective To investigate the effects of dexmedetomidine on heart rate variability of elderly patients during the induction of general anesthesia.Methods Fifty cases of elderly patients with general anesthesia,ASA ⅠorⅡ,were randomly divided into dexmedetomidine group（group D）and normal saline group（group C）,25 cases in each group.Group D received 20 ml infusion that contained 0.5μg/kg dexmedetomidine within 10 minutes before induction of general anesthesia and received the same infusion with a constant speed of 0.3μg·kg-1·h-1 untill 5minutes after intubation;Group C received the infusion of normal saline（NS）in the same way.The total power（TP）,relative low frequency（LF）,relative high frequency（HF）,and the ratio of low frequency to high frequency（L/H）were recorded after entered the operating room（T0）and the moment after the dexmedetomidine infusion（T1）,before（T2）and 1 min（T3）,3 min（T4）,5 min（T5）after indubation.Results Compared to T1,LF at T3-T5,HF at T4,T5 and TP at T5 in group D were significantly increased and LF/HF was significantly decreased at T3-T5（P〈0.05）;Compared to group C,LF at T3-T5,HF and TP at T2-T5 were increased significantly and LF/HF was significantly decreased at T1-T5（P〈0.05）.Conclusion Dexmedetomidine infusion during induction of general anesthesia can increase heart rate variability and balance the sympathetic and the vagus nerve tension,maintain the stability of cardiovascular function.
出处
《临床麻醉学杂志》
CAS
CSCD
北大核心
2014年第9期867-869,共3页
Journal of Clinical Anesthesiology
关键词
右美托咪定
心率变异性
老年
麻醉诱导
Dexmedetomidine
Heart rate variability
Elderly
Anesthesia induction
