摘要
目的:探讨乙型肝炎病毒及幽门螺杆菌感染对慢性乙型肝炎患者胃粘膜病情变化的影响。方法:对60例感染慢性乙型肝炎病毒的感染者用酶联免疫吸附法(ELISA)检测血清中乙型肝炎病毒表面抗原和乙型肝炎病毒核心抗原及幽门螺旋杆菌抗原;免疫组织化学法(Envision)检测胃粘膜组织中三者抗原,同时联合快速尿素酶。分为慢性乙型肝炎组和肝硬化组两组,每组30例,肝硬化组再分为食管静脉曲张组和无食管静脉曲张组,每组15例。同时选择30例无肝病的胃炎患者为对照组。结果:29例经胃镜检测发现乙型肝炎病毒,且其中20例患者胃粘膜组织有异常病变,病变主要以中、重度为主,占患者总数的68.97%。31例患者的胃部粘膜组织中组织异常,其炎性病变以轻、中度为主,占70.97%。差别具有统计学意义(P<0.05)。慢性乙型肝炎病毒感染者胃粘膜组织中乙肝病毒表面抗原和乙肝病毒核心抗原均为阳性的胃粘膜病变的程度较重。胃粘膜有炎症表达的幽门螺旋杆菌的感染率在慢性乙型肝炎组和肝硬化组分别为77.78%和79.31%,无肝病的胃炎组的感染率为56.70%,各组间无显著性的差别,且差别无统计学意义(P>0.05)。结论:乙型肝炎病毒是感染者胃粘膜病变的主要诱因之一,且与胃粘膜病变程度有关;幽门螺旋杆菌感染和慢性乙型肝炎患者胃粘膜病变程度之间无显著关联性。
Objective：To analyze the relations between hepatitis B virus markers and helicobacter pylori in patients with hepatitis B virus infection in gastric mucosa, the effect of HBV and helicobacter pylori infection on gastric mucosa in chronic hepatitis B patients .Method：Choose 60 cases patients with chronic HBV infection diagnosed by serum HBV DNA examination .HBV in serum were exterminated with ELISA , while HBsAg and HBcAg and HP-IgG in gastric mucosa were exterminated by immunohistochemistry .Uresase detection , HE, Fuchsin staining and immunohistochemical analysis of helicobacter pylori IgG antigen were conducted .Result：29 cases of gastric mucosa in 60 cases of hepatitis B virus infection in can be detected in hepa-titis B virus, of which 20 patients with gastric tissue abnormalities , inflammatory lesions in the gastric mucosa moderate , se-vere, accounting for 68.97%.31 cases of chronic hepatitis B virus infection in gastric mucosa tissue abnormalities , inflammato-ry lesions with its mild, moderate, accounting for 70.97%.The difference was statistically significant （P 〈0.05）.The degree of chronic hepatitis B virus infection in gastric mucosa surface antigen of hepatitis B virus and hepatitis B virus core antigen -positive patients were heavier gastric lesions .Expression of gastric inflammation in patients with H .pylori infection rate was 77. 78%and 79.31%, respectively , in patients with chronic hepatitis and cirrhosis patients , Helicobacter gastritis patients without liver disease pylori infection rate was 56.70%,There＇s no significant difference by comparison among groups , the difference has no statistically significant （P〉0.05）.Conclusion： HBV can be found growing and copying in gastric mucosa , and also be found to be an important factor of gastric mucosa lesions in HBV infection patients;the damage of gastric mucosa with the infec-tion of HBV in the gastric mucosa in the HBV infection patients is of correlation;NO relationship between HBV and Helicobact-er pillories press ions was observed in gastric mucosa , there＇s no significant association between infection and gastric mucosal lesions in chronic hepatitis B patients of Helicobacter pylori.
出处
《河北医学》
CAS
2014年第12期1964-1968,共5页
Hebei Medicine
基金
广东省深圳市盐田区科技计划资助项目
(编号:2012001)
关键词
乙型肝炎病毒
粘膜病变
幽门螺杆菌
Hepatitis B virus
Mucosal lesions
Helicobacter pylori
