摘要
目的 通过Meta分析的方法对川芎嗪治疗急性胰腺炎的疗效进行评价.方法 计算机检索WANFANG（1999～2013）、VIP（1989 ～2013）、CNKI（1994 ～ 2013）及CAJD数据库中关于川芎嗪治疗胰腺炎的临床随机对照试验（RCT）,对符合要求的RCT进行Meta分析.结果 最终纳入13篇RCT,有1 083例患者符合纳入标准.Meta分析结果显示,川芎嗪治疗组的临床疗效（总效应Z =4.33,OR =4.72,95％ CI2.34～9.53,P＜0.01）、并发症（总效应Z=5.50,OR=0.29,95％ CI0.19 ～0.45,P＜0.01）、死亡率（总效应Z=2.18,OR =0.50,95％ CI0.27 ～ 0.93,P=0.03）、住院时间（总效应Z=4.66,MD=-5.43,95％ CI-7.71 ～-3.15,P＜0.01）均明显优于对照组（P＜0.05）.结论 在常规综合治疗基础上,川芎嗪对急性胰腺炎疗效确切,其可显著地提高AP的临床疗效,缩短患者住院时间,降低并发症,减少死亡率.
Objective To investigate the effectiveness of tetramethylpyrazine in the treatment of severe acute pancreatitis （SAP）,with a meta-analysis on the published data.Methods A comprehensive search was performed in WANFANG （1999 ～ 2013）,VIP （1989 ～2013）,CNKI （1994 ～ 2013）,and CAJD databases to collect the randomized controlled trials （RCTs） that used tetramethylpyrazine in the treatment of SAP.Those RCTs were analyzed with meta-analysis method.Results A total of 1 083 patients was analyzed in the 13 RCTs that met the inclusion criteria.The meta-analysis results suggested that,compared to the control group,patients had a significantly clinical efficacy （test for overall effect：Z =4.33,OR =4.72,95％ CI 2.34 ～ 9.53,P ＜ 0.01）,lower complication （test for overall effect：Z =5.50,OR =0.29,95％ CI 0.19 ～ 0.45,P ＜ 0.01）,less hospital stay （test for overall effect：Z =2.18,OR =0.50,95％ CI0.27 ～0.93,P =0.03）,and hospital death （test for overall effect：Z =4.66,MD =-5.43,95％ CI-7.71 ～-3.15,P ＜ 0.01） in tetramethylpyrazine group （P ＜ 0.05）.Conclusions On the basis of conventional therapy,the effectiveness of tetramethylpyrazine is positive,it is able to significantly increase clinical efficacy with a low complication,decrease hospital death,and shorten hospital stay.
出处
《中国医师杂志》
CAS
2014年第8期1071-1075,共5页
Journal of Chinese Physician
关键词
川芎嗪/治疗应用
胰腺炎/药物疗法
急性病
治疗结果
随机对照试验
Meta分析
TETRAMETHYLPYRAZINE/therapeutic use
Pancreatitis/drug therapy
Acute disease
Treatment outcome
Randomized controlled trial
Meta-analysis
