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糖尿病动物模型心功能评价方法 被引量:5

Evaluation of cardiac function in diabetic animal models
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摘要 糖尿病心血管并发症(cardiovascular complications of diabetes,CCD)是糖尿病患者最主要的死亡原因,其中糖尿病心肌病(diabetic cardiomyopathy,DC)是心力衰竭的主要原因。对于分析糖尿病心肌病的机制、早期诊断以及改进和优化治疗,心脏功能评估起到重要桥梁作用,而糖尿病动物模型直接或间接反映糖尿病的发生和发展过程,是一个良好的研究载体。本文旨在综述国内外糖尿病动物模型心脏功能评价的重要方法。 Cardiovascular complication of diabetes ( CCD) is a leading cause of mortality in diabetic patients , and diabetic cardiomyopathy ( DC) vastly accounts for heart failure in those CCD patients .In the research of pathogenesis , early diagnosis and better treatment of DC , cardiac function evaluation plays a key bridging role .Addtionally , animal models may well simulate the development of diabetes .The purpose of this article is to review the important methods in evaluating heart function of diabetes animal models .
作者 孟哲颖 申锷
出处 《中国实验动物学报》 CAS CSCD 2014年第4期86-89,共4页 Acta Laboratorium Animalis Scientia Sinica
基金 国家自然科学基金面上项目(NO.81270208)
关键词 糖尿病心血管并发症 糖尿病心肌病 心脏功能 模型 动物 Cardiovascular complications Diabetes mellitus Diabetic cardiomyopathy Cardiac function Mod-els,animal
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