摘要
目的 研究桑叶总黄酮对非酶糖基化的抑制作用。方法 从桑叶中提取不同浓度 (0 0 0 1,0 0 1,0 1g/L)总黄酮加入体外白蛋白糖基化体系中 ,分别孵育 1,4 ,7,14 ,2 1,2 8天 ,测定早期糖化白蛋白产物的浓度。结果 糖化蛋白产量与孵育时间呈正相关 ,桑叶总黄酮 (0 1g/L)在各时间点均使糖化蛋白生成较对照组少。 结论 蛋白质非酶糖化与葡萄糖孵育时间正相关 。
Objective To investigate the inhibitory effect of flavonoids from morus folium on the nonenzymatic glycosylation.Methods The flavonoids from extracts of morus folium in different concenration (0.001,0.01,0.1 g/L) were added to a glycosylation system in vitro,and incubated for 1,4,7,14,21 ,28 days respectively,then the early glycasylation products were measured.Results The quantity of the early nonenzymatic glycosylation products had positive correlation with the incubating time,and each incresed significantly when the extracts added.Conclusion There was positive correlation between nonenzymatic glucosylation and incubating time in this system,and the falvonoids from morus foliuna may possess inhibitory effects on nonenzymatic glucosylation in vitro.
出处
《中国公共卫生》
CAS
CSCD
北大核心
2002年第8期929-930,共2页
Chinese Journal of Public Health
