摘要
目的 研究中度高血压患者血压晨峰与心肌重塑的关系.方法 对60例中度高血压患者进行24小时动态血压监测,将其中有血压晨峰现象的患者24例作为试验组,无血压晨峰者36例作为对照组.应用超声心动仪测定两组患者室间隔厚度（IVS）、左心室后壁厚度（LVPWT）、左心房内径（LAD）、左心室舒张末期内径（LVDd）和左心室质量指数（LVMI）,检测其空腹血浆B型脑钠肽（BNP）、血清超敏C反应蛋白（hs-CRP）水平.结果 试验组患者IVS、LVPWT、LAD、LVDd及LVMI均明显高于对照组（P＜0.05）,试验组BNP及hs-CRP水平显著高于对照组,差异有统计学意义（P＜0.05）.结论 血压晨峰比无血压晨峰现象的高血压患者的左心室心肌肥厚更加明显,血浆BNP及hs-CRP水平更高,提示血压晨峰现象与心肌重塑可能有密切关系.
Objective Study on the relationship between morning blood pressure surge of patients with moderate hypertension and myocardial remodeling. Methods Collection of 60 patients with moderate hypertensive for 24 hours ambulatory blood pressure monitoring（ABPM） ,including 24 patients with morning blood pressure surge as a trial group and no morning blood pressure surge in 36 cases as control group. Interventricular septum（IVS） ,left ventricular posterior wall thickness （LVPWT） , left atrial diame- ter（ LAD）, left ventricular end-diastolic diameter （LVDd） and left ventricular mass index （LVMI） were assessed from the B-ultrasound. Determination of two patients groups with fasting plasma B-Type Natriuret- ic peptide（BNP） and Serum high sensitivity C-reactive protein（hs-CRP） level. Results IVS, LVPWT, LAD, LVDd and LVMI in trial group are significantly higher than the control group （ P 〈 O. 05 ）. In trial group BNP and hs-CRP are significantly higher than the control grorp （P 〈 0.05 ）. Conclusion Morning blood pressure surge is more obvious than that of cardiac hypertrophy whithout morning blood pressure surge in patients with left ventricular, the level of BNP and hs-CRP are higher in plasma that morning blood pressure may be closely related to myocardial remodeling.
出处
《临床内科杂志》
CAS
2014年第8期553-555,共3页
Journal of Clinical Internal Medicine
关键词
高血压
血压晨峰
心肌重塑
B型脑钠肽
超敏C反应蛋白
Hypertension
Morning blood pressure surge
Myocardial remodiling
B-type natriuretic peptide
High sensitivity C reactive protein
