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长链非编码 RNA在原发性肝癌中的临床应用 被引量:5

Advances of long noncoding RNA in primary liver cancer
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摘要 长链非编码RNA(long noncoding RNA, lncRNA)是一类长度大于200nt、不能编码蛋白质的RNA,参与了基因调控的各个层面。近来的研究发现,多种lncRNA在肝癌组织中表达异常,可能在肝癌发生、发展中起着重要的调控作用。(中华检验医学杂志,2014,37:665-668) LncRNAs( long noncoding RNAs ) can be defined as RNA transcrips longer than 200nt without protein coding capacity , which play vital roles in various aspects of gene expression regulation.Recent investigations showed aberrant expression of many lncRNAs in primary liver cancer , indicating their important roles in tumorigenesis and development of liver cancer.This review focuses on the biological functions of lncRNAs and their involvements in primary liver cancer.
作者 任婷玉 郑磊
出处 《中华检验医学杂志》 CAS CSCD 北大核心 2014年第9期665-668,共4页 Chinese Journal of Laboratory Medicine
基金 国家自然科学基金资助项目(81371901) 教育部博士点基金资助项目(20134433110010)
关键词 肝肿瘤 RNA 长链非编码 Liver neoplasms RNA,long noncoding
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