冠状动脉内注射半剂量替罗非班对老年急诊PCI心肌梗死患者术中慢血流的有效性及安全性分析被引量：1

Safety and efficacy of intracoronary injection of half dose tirofiban for slow blood flow in elderly patients with myocardial infarction during emergency PCI operation

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摘要目的探讨冠状动脉内注射半剂量替罗非班对老年急诊经皮冠状动脉介入治疗(PCI)心肌梗死患者术中慢血流的有效性及安全性。方法 98例老年急诊PCI术中出现慢血流的心肌梗死患者,随机分为A组和B组,各49例,分别于冠状动脉内给予5μg/kg和10μg/kg替罗非班,比较两组患者血浆C-反应蛋白、血清肌酸激酶同工酶和心肌肌钙蛋白I、心血管事件和术后3 d内出血情况。结果入组时和术后第3天,两组患者血浆C-反应蛋白、血清肌酸激酶同工酶和心肌肌钙蛋白I差异无统计学意义(P>0.05)。两组患者主要心血管事件发生率差异无统计学意义(P>0.05)。两组患者无血红蛋白、血球压积和血小板计数下降,也未见过敏性反应等。A组患者出现轻度出血2例(4.08%),B组3例(6.12%),两组比较差异无统计学意义(P>0.05)。结论冠状动脉内注射半剂量替罗非班对老年急诊PCI心肌梗死患者术中慢血流临床疗效确切,具有安全高效和不良反应少等优点,值得在临床上推广应用。 Objective To explore the safety and efficacy of intracoronary injection of half dose of tirofiban for the slow flow in elderly patients with acute myocardial infarction during emergency percutaneous coronary interven -tion（ PCI） operation.Methods Ninety-eight elderly patients with myocardial infarction who had slow flow during e -mergency PCI operation were randomly divided into A group and B group , with 49 cases in each group , and were giv-en 5 μg/kg and 10μg/kg tirofiban in the coronary artery respectively .Between two groups the plasma C-reactive pro-tein, serum creatine kinase MB and cardiac troponin I , cardiovascular events , bleeding with in 3 days after operation were compared .Results Baseline and third day after operation , the two groups had no statistically significant differ-ence in serum C-reactive protein , serum creatine kinase MB and cardiac troponin I （ P〉0.05 ） .Two groups had no decrease in hemoglobin , hematocrit and platelet counts , no allergic reaction was found .2 cases of mild bleeding in A group（4.08%）, 3 case of mild bleeding in B group （6.12%）, no significant difference between two groups （P〉0.05 ） .Conclusion Intracoronary injection of half dose of tirofiban has the exact efficacy on slow flow of elderly my -ocardial infarctionin patients undergoing emergency PCI , and is safe and effective with less adverse reaction , and is worth of clinical application .

作者梁鹍

机构地区郑州大学第五附属医院心内三科

出处《中国临床新医学》 2014年第9期829-831,共3页 CHINESE JOURNAL OF NEW CLINICAL MEDICINE

关键词冠状动脉盐酸替罗非班急诊经皮冠状动脉介入治疗急性心肌梗死慢血流 Coronary artery Tirofiban hydrochloride Emergency percutaneous coronary intervention（PCI） Acute myocardial infarction Slow flow

分类号 R54 [医药卫生—心血管疾病]

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