摘要
脑膜转移是肺癌最严重的并发症之一,患者预后极差。脑膜转移患者临床表现缺乏特异性,主要表现为脑、脑神经、脊神经受累症状。目前诊断主要依据肿瘤病史、临床症状、增强核磁共振(magnetic resnance image,MRI)扫描和脑脊液细胞学检查。近年来新的检测方式在临床上不断涌现,明显提高了脑膜转移的早期发现率,但肺癌脑膜转移的综合治疗疗效仍不令人满意。本文就肺癌脑膜转移的病理生理、临床表现、诊断方法及治疗疗效的研究进展做一综述。
Leptomeningeal metastases is one of the most serious complications of lung cancer, the patients with poor prognosis. Leptomeningeal metastasis in patients with lack speciifcity of clinical manifestations. hTe main clinical perfor-mance are the damage of cerebral symptoms, cranial nerve and spinal nerve. hTe diagnosis primarily based on the history of tumor, clinical symptoms, enhance magnetic resnance image （MRI） scan and cerebrospinal lfuid cytology. In recent years, new ways of detecting clinically, signiifcantly increase the rate of early detection of leptomeningeal metastases. hTe effect of compre-hensive treatments are still sad. hTe paper make a review of research progress in pathologic physiology, clinical manifestations, diagnosis methods and treatments of lung cancer with leptomeningeal metastases.
出处
《中国肺癌杂志》
CAS
北大核心
2014年第9期695-700,共6页
Chinese Journal of Lung Cancer
关键词
肺肿瘤
脑膜转移
诊断
治疗
Lung neoplasms
Leptomeningeal metastases
Diagnosis
Treatments
