摘要
目的:研究P-p38和uPA蛋白的表达与大肠癌生物学行为及预后的关系。方法:应用免疫组织化学(SP)法检测P-p38和uPA在62例大肠癌、25例大肠腺瘤及18例正常大肠黏膜组织中的表达。结果:大肠癌组织中P-p38和uPA阳性表达率分别为79.0%和74.2%,均明显高于大肠腺瘤及正常大肠黏膜组织,差异有显著统计学意义(P<0.05)。P-p38和uPA表达与大肠癌的分化程度、淋巴结转移、Duke's分期及浸润肌层的深度密切相关(P<0.05),且两者表达成明显正相关(P<0.05)。P-p38和uPA表达阳性者术后5年生存率明显低于阴性者,差异有显著意义(P<0.05)。结论:P-p38和uPA的高表达预示着大肠癌的低分化,并共同促进了肿瘤的侵袭、转移。联合检测P-p38和uPA的表达情况对于评估大肠癌的发展及预后具有重要意义。
Objective：To study the expression of P-p38 and uPA in colorectal carcinoma and their relationship with the biological behavior and prognosis. Methods：SP immunochemical method was performed to detect the expres-sion of P-p38 and uPA in 62 cases of colorectal carcinoma,25 cases of colorectal adenomas,and 18 cases of normal colorectal tissues. Results：The positive rates of P-p38 and uPA in colorectal cancers（79. 0%,74. 2% respectively） were significantly higher than those in the colorectal adenomas and normal colorectal tissues group（P〈0.05）.Theex-pressions of P-p38 and uPA were closely related to pathological differentiation,lymph node metastasis,Duke＆#39;s stages and the deepnessofinvasion（P〈0.05）.The expression of P-p38 was significantly correlated with uPA（P〈0.05）. The 5 years survival rates after operation in positive expression groups of P-p38 and uPA were significantly lower than those in negative expression groups. Conclusion：Overexpression of P -p38 and uPA in colorectal carcinoma were associated with poorly histological grades,cell migration,tumormetastases and poor prognosis. It is very signifi-cant to investigate the expression of P-p38 and uPA combinedly in colorectal carcinoma.
出处
《现代肿瘤医学》
CAS
2014年第10期2374-2377,共4页
Journal of Modern Oncology
