摘要
目的分析白色念珠菌引起抗菌药物相关性腹泻(AAD)的临床检验特点。方法对100例AAD患者粪便标本进行细菌培养,根据所得结果分为白色念珠菌感染组和非白色念珠菌感染组,对比2组患者血钠、血钾、空腹血糖和清蛋白水平,以及抗菌药物使用情况和药物敏感试验结果。结果细菌培养检出白色念珠菌42例。白色念珠菌感染组血钠、血钾和空腹血糖水平明显高于非白色念珠菌感染组(P<0.01),而清蛋白水平明显低于非白色念珠菌感染组(P<0.01)。白色念珠菌感染组的二联及以上抗菌药物使用率明显高于非白色念珠菌感染组(P<0.05)。白色念珠菌感染组对氟康唑、伊曲康唑、伏立康唑、两性霉素B和氟胞嘧啶的耐药率明显低于非白色念珠菌感染组(P<0.05),而敏感率明显高于非白色念珠菌感染组(P<0.05);白色念珠菌感染组对万古霉素、呋喃妥因的耐药率明显高于非白色念珠菌感染组(P<0.01),而敏感率明显低于非白色念珠菌感染组(P<0.01)。结论对于ADD患者,进行粪便培养可以为临床治疗提供诊断依据,避免抗菌药物滥用。
Objective To analyze the clinical laboratory characteristic of Candida albicans caused antibiotic-associated diarrhea （AAD） .Methods 100 cases of AAD were selected .Based on the results ,they were divided into Candida albicans group and non-Candida albicans group .The levels of sodium ,potassium ,fasting blood-glucose and albumin ,investigation of antimicrobial usage were compared in two groups .Results Candida albicans were detected in 42 cases .The levels of sodium ,potassium and fasting blood-glucose in the Candida albicans group were significantly higher than those in non-Candida albicans group（P〈0 .01） ,and al-bumin were significantly lower than that in non-Candida albicans group（P〈 0 .01） .The rate of two or more antibiotic usage in Candida albicans group was significantly higher than that in non-Candida albicans group（P〈0 .05） .The drug resistance rates of fluconazole ,itraconazole ,voriconazole ,amphotericin B and flucytosine in Candida albicans group were significantly lower than those in non-Candida albicans group（P〈0 .05） ,and the antibiotic sensitive rates of fluconazole ,itraconazole ,voriconazole ,amphotericin B and flucytosine in Candida albicans group were significantly higher than those in non-Candida albicans group（P〈0 .05） .The drug resistance rates of vancomycin and macrodantin in Candida albicans group were significantly higher than those in non-Candida al-bicans group（P〈0 .01） ,and the antibiotic sensitive rates of vancomycin and macrodantin in Candida albicans group were signifi-cantly lower than those in non-Candida albicans group（P〈0 .01） .Conclusion For AAD cases ,the fecal culture can provide exper-imental basis for clinical treatment and avoid the abuse of antibiotics .
出处
《国际检验医学杂志》
CAS
2014年第19期2586-2588,共3页
International Journal of Laboratory Medicine
基金
江西省卫生厅科技项目(20122030)
关键词
抗菌药物相关性腹泻
临床检验
耐药性
antibiotic-associated diarrhea
clinical laboratory
resistance
