摘要
目的:探讨针对胃溃疡(gastric ulcer,GU)活动期毒热病因要素的中药干预效果.方法:按照随机数字表法将江西中医药大学附属医院收治的98例GU患者均分为实验组和对照组,实验组患者给予解毒消痈冲剂治疗,对照组患者给予安胃疡胶囊治疗,比较两组患者治疗后中医症状评分改善情况、黄苔或黄腻苔、白腻苔消失率、幽门螺杆菌(Helicobacter pylori,H.pylori)根除率、临床疗效以及治疗期间不良反应发生情况.结果:两组患者治疗后各项中医症状评分均显著下降,与治疗前比较,(1.31±1.22 vs 4.11±1.42)、(0.91±1.19 vs 3.02±1.11)、(0.92±1.29 vs 3.13±1.06)、(0.50±0.71 vs 1.98±0.91)、(0.42±0.39 vs 1.84±0.69)、(0.62±0.60 vs 1.61±0.80),(2.33±1.30 vs 4.12±1.40)、(1.52±1.38 vs 2.98±1.10)、(1.60±0.88 vs 3.12±1.08)、(1.01±0.69 vs 2.00±0.88)、(0.79±0.80 vs 1.82±0.80)、(0.91±0.79 vs 1.62±0.79),差异具有统计学意义(P<0.05);实验组患者治疗后各项中医症状评分下降幅度均显著高于对照组,(1.31±1.22vs 2.33±1.30)、(0.91±1.19 vs 1.52±1.38)、(0.92±1.29 vs 1.60±0.88)、(0.50±0.71 vs1.01±0.69)、(0.42±0.39 vs 0.79±0.80)、(0.62±0.60 vs 0.91±0.79),差异具有统计学意义(P<0.05);实验组患者治疗后黄苔或黄腻苔、白腻苔消失率和H.pylori根除率均显著高于对照组,(77.55%vs 42.86%)、(65.31%vs38.78%),差异具有统计学意义(P<0.05);实验组患者痊愈率和总有效率均显著高于对照组,(67.35%vs 34.69%)、(97.96%vs 75.51%),差异具有统计学意义(P<0.05).结论:解毒消痈冲剂能够有效改善GU患者中医症状和舌像,H.pylori根除率高,临床疗效显著,无不良反应,可作为治疗活动期GU的优选药物.
AIM： To assess the clinical effects of Jiedu Xiaoy- ong granules in the treatment of active gastric ulcer （GU）. METHODS： Ninety-eight patients with active GU were randomly divided into either an ex- periment group or a control group. The experi- ment group was treated with Jiedu Xiaoyong granules, and the control group was treated with Anweiyang capsules. The traditional Chinese medicine symptom scores, the disappearance rates of yellow tongue coating and white greasy moss, the eradication rate of Helicobacter pylori （H. pylori）, clinical effect and adverse reactions were compared between the two groups. RESULTS： The scores of traditional Chinese med- icine symptoms in both groups were significantly lower after treatment than before treatment （1.31± 1.22 vs 4.11 ± 1.42, 0.91 ± 1.19 vs 3.02 ± 1.11, 0.92 ± 1.29 vs 3.13 ± 1.06, 0.50 ± 0.71 vs 1.98 ± 0.91, 0.42 ± 0.39 vs 1.84 ± 0.69, 0.62 ± 0.60 vs 1.61 ± 0.80, 2.33 ± 1.30 vs 4.12 ± 1.40, 1.52 ± 1.38 vs 2.98 ± 1.10, 1.60 ± 0.88 vs 3.12 ± 1.08, 1.01 ± 0.69 vs 2.00 ± 0.88, 0.79 ± 0.80 vs 1.82 ± 0.80, 0.91 ± 0.79 vs 1.62 ± 0.79; P 〈 0.05）; the decreases in the scores of traditional Chi- nese medicine symptoms in the experiment group were significantly higher than those in the control group （1.31 ± 1.22 vs 2.33 ± 1.30, 0.91 ± 1.19 vs 1.52 ± 1.38, 0.92 ± 1.29 vs 1.60 ± 0.88, 0.50 ± 0.71 vs 1.01 ± 0.69, 0.42 ± 0.39 vs 0.79 ± 0.80, 0.62 ± 0.60 vs 0.91 ± 0.79; P 〈 0.05）. The disappearance rates of yellow tongue coating and white greasy moss as well as the eradication rate of H. pylori in the experiment group were significantly higher than those in the control group （77.55% vs 42.86%, 65.31% vs 38.78%; P 〈 0.05）. The recovery rate and total effective rate in the experiment group were also significantly higher than those in the control group （67.35% vs 34.69%, 97.96% vs 75.51%; P 〈 0.05）. CONGLUSION： Jiedu Xiaoyong granules can improve Chinese medicine symptoms and tongue image in patients with active GU, and is associated with a high eradication rate of H. pylori, distinct clinical effects, and very few ad- verse reactions.
出处
《世界华人消化杂志》
CAS
北大核心
2014年第26期3968-3971,共4页
World Chinese Journal of Digestology
关键词
胃溃疡
毒热
解毒消痈冲剂
安胃疡胶囊
干预效果
Gastric ulcer
Heat toxicity
Jiedu Xi-aoyong granules
Anweiyang capsules
Interventioneffect
