摘要
目的探讨淋巴细胞人类白细胞抗原-DR(HLA-DR)分子表达在重型乙型肝炎中的免疫作用及其临床意义。方法收集46例慢性乙型肝炎(CHB)患者、24例慢性重型乙型肝炎(CHF)患者和20例健康体检者的外周血,采用流式细胞仪检测其淋巴细胞HLA-DR分子表达情况及肝功能等指标。结果健康对照组、CHB组和CHF组HLA-DR分别为(31.27±9.78)%、(32.86±10.56)%和(24.29±9.87)%,CHF组明显低于健康对照组,差异有统计学意义。死亡组HLA-DR为(15.27±5.15)%明显低于生存组(27.29±9.26)%,差异有统计学意义(t=-3.99,P=0.007)。HLA-DR与ALT和PT呈正相关关系(r分别为0.463和0.628,P分别为0.023和0.001)。结论淋巴细胞HLA-DR水平与CHF患者的免疫状态、病情及其预后具有重要关系。
Objective To investigate the function and clinical significance of HLA-DR in chronic severe hepatitis B （CSHB）patients.Methods HLA-DR levels in 46 cases of chronic hepatitis B （CHB）,24 cases of CSHB and 20 cases of healthy controls （HC）were detected by flow cytometry,and biochemical indicators of the recruits were collected.Results HLA-DR levels in HC,CHB and CSHB group were 31 .27 ＆#177;9.78、32.86 ＆#177;10.56 and 24.29 ＆#177;9.87,respectively. There was a significantly lower HLA-DR level in CSHB group,compared with HC group （P ＆lt;0.05）.The death group （15.27＆#177;5.15 ）had a obviously lower HLA-DR level than that of survival group （27.29 ＆#177;9.26）,reaching statistical significance （P ＆lt;0.05）.Furthermore,HLA-DR levels was positively correlated with albumin and prothrombin （r were 0.463 and 0.628,respectively;P were 0.023 and 0.023,respectively）.Conclusions The lymphocytes HLA-DR plays an important role in the immune state,condition and prognosis of chronic severe hepatitis B.Thus,to a certain extent, HLA-DR level could help to evaluate the prognosis of diseases and guide clinical therapy.
出处
《肝脏》
2014年第7期487-490,共4页
Chinese Hepatology
基金
福建医科大学非直属附属医院科研发展专项基金资助(FZS13029Y)
福建省医学创新课题(2012-CX-33)
