摘要
用熔融-乳化法制备葫芦素B纳米脂质载体,以平均粒径、包封率和载药量为评价指标,采用星点设计-效应面法优化处方。所得优化处方为单硬脂酸甘油酯0.3 g、卵磷脂0.125 g、注射用大豆油0.075 g、聚乙二醇40硬脂酸酯0.2 g。优化处方平均粒径、包封率和载药量的实测值分别为120.8 nm、83.3%和0.83%,并与预测值相近。制品在45.5 h时体外释放率可达(87.1±3.5)%,且体外释放行为符合一级动力学模型。
The nanostructured lipid carriers loaded with cucurbitacin B were prepared by melt-emulsification method.Central composite design-response surface methodology （CCD-RSM） was utilized to optimize the formulation with average particle size,entrapment efficiency and drug loading as evaluation indexes.The optimal formulation was as follows：glycerin monostearate was 0.3 g,lecithin was 0.125 g,soybean oil of injection was 0.075 g and polyethylene glycol 40 stearate was 0.2 g.The measured values of average particle size,entrapment efficiency and drug loading for the optimal product were 120.8 nm,83.3 ％ and 0.83 ％,respectively.And these measured values were close to the predicted values.The cumulative amount at 45.5 h was （87.1±3.5） ％ and the first-order kinetic model gave a good fit to the in vitro release data.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2014年第11期1042-1045,1077,共5页
Chinese Journal of Pharmaceuticals
基金
黑龙江省教育厅面上项目资助(12531787)
关键词
葫芦素B
纳米脂质载体
星点设计-效应面优化法
cucurbitacin B
nanostructured lipid carrier（NLC）
central composite design-response surface methodology （CCD-RSM）
