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树枝状大分子纳米载体作为脑靶向给药系统的研究进展 被引量:4

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摘要 血脑屏障在保护中枢神经系统中发挥了重要的作用,但也阻碍了药物或者诊断剂向脑部递送。本文根据近年来国内外文献资料,针对树枝状大分子纳米载体不同的修饰方法在脑靶向系统的应用进行归纳总结。修饰后的树枝状大分子作为向脑部递送药物或者基因的系统载体具有良好的应用前景。
作者 任荣 李正翔
出处 《天津药学》 2014年第5期54-58,共5页 Tianjin Pharmacy
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  • 1Jones A R, Shusta E V. Blood brain barrier transport of therapeutics via receptor mediation [ J ]. Pharm Res,2007, 24 ( 9 ) : 1759.
  • 2Pradridge W M. Molecular Trojan horses for bloodbrain barrier th'ug de- livery[J]. Curr Opin Phamlacol, 2006, 6(5 ) :494.
  • 3Kreuter J, Swarbrcik J C. Encyclopedia of Pharmaceutical Tethnology [ M ]. Third Edition Volume Set. NewYork : Maecel, 1994 :1 65.
  • 4Grayson M S, Freehet J M J. Convergent dendrons and dendrimers[ J]. Chem Rev,2001 ,101:3819.
  • 5Bosman W A, Janssen M H, Meijer W. About dendrimers: structure, physical property and functions [ J ]. Chem Rev, 1999, 99 (7) : 1665.
  • 6Huang R Q, Qu Y H, Ke W L, et al. Efficient gene delivery targeted to the brain using a transferrin - conjugated polyethyleneglycol - modified polyamidoamine dendrimer[ J ]. Faseb J,2007,21 : 1117.
  • 7He H, Li Y, Jia X R, et al. PEGylated Poly(amidoarnine) dendrimer - based dual - targeting carrier for treating brain tumors[ J]. Biomateri- als,2011 ,32(2) :478.
  • 8Li Y, He H, Jia X, et al. A dual -targeting nanocarrier based on poly (amidoamine) dendrimers conjugated with transirrin and tamoxifen for treating brain gliomas[J]. Biomaterials, 2012, 33:3899.
  • 9曹阳,包永明,安利佳,高华颖.乳铁蛋白研究现状[J].食品科学,2002,23(12):132-138. 被引量:15
  • 10Huang R, Ke W, Han L, et al. Brain - targeting mechanisms of lacto-. fen'in - modified DNA - loaded nanoparticles [ J ]. J Cereb Blood Flow Metab, 2009,29 ( 12 ) : 1914.

二级参考文献26

  • 1尤永平,常津,傅震,刘宁,浦佩玉.超微载体介导反义端粒酶RNA抑制胶质瘤细胞生长的研究[J].中华实验外科杂志,2004,21(11):1296-1297. 被引量:5
  • 2[1]Devile C,Packer R,Walker D,et al.What's new in neuro-on-cology.Eur J Paediatr Neurol,2000,4:255-262.
  • 3[2]Kyo S,Inoue M.Complex regulatory mechanisms of telomerase activity in normal and cancer cells:how can we apply them for cancer therapy? Oncogene,2002,21:688-697.
  • 4[3]Le S,Zhu JJ,Anthony DC,et al.Telomerase activity in human gliomas.Neurosurgery,1998,42:1120-1125.
  • 5[5]Kraemer K,Fuessel S,Schmidt U,et al.Antisense-mediated hTERT inhibition specifically reduces the growth of human bladder cancer cells.Clin Cancer Res,2003,9(10 Pt 1):3794-3800.
  • 6[6]Cao Y,Li H,Deb S,et al.TERT regulates cell survival independent of telomerase enzymatic activity.Oncogene,2002,21:3130-3138.
  • 7[7]Zhang L,Yang N,Mohamed-Hadley A,et al.Vector-based RNAi,a novel tool for isoform-specific knock-down of VEGF and antiangiogenesis gene therapy of cancer.Biochem Biophys Res Commun,2003,303:1169-1178.
  • 8[8]Sui G,Soohoo C,Affar el B,et al.A DNA vector-based RNAi technology to suppress gene expression in mammalian cells.Proc Natl Acad Sci USA,2002,99:5515-5520.
  • 9[9]Brummelkamp TR,Bernards R,Agami R.A system for stable expression of short interfering RNAs in mammalian cells.Science,2002,296:550-553.
  • 10[10]Kosciolek BA,Kalantidis K,Tabler M,et al.Inhibition of telomerase activity in human cancer cells by RNA interference.Mol Cancer Ther,2003,2:209-216.

共引文献34

同被引文献113

  • 1张阿方.树枝化聚合物的合成、结构表征及其应用[J].化学进展,2005,17(1):157-171. 被引量:25
  • 2朱瀛,陆伟根.磁性微球和磁性纳米粒的研究进展[J].中国医药工业杂志,2005,36(9):581-584. 被引量:24
  • 3Ostrom QT, Gittleman H, Fulop J, et al. CBTRUS Statistical Report: Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2008-2012 [J]. Neuro Oncol, 2015, 17 Suppl 4: ivl-iv62, doi: 10,1093/neuonc/nov189.
  • 4Ellis HP, Greenslade M, Powell B, et al. Current Challenges in Glioblastoma: Intratumour Heterogeneity, Residual Dis- ease, and Models to Predict Disease Recurrence [J]. Front Oncol, 2015, 5: 251. doi: 10.3389/fonc,2015.00251.
  • 5Lima FR, Kahn SA, Soletti RC, et al. Glioblastoma: therapeutic challenges, what lies ahead [J]. Biochim Biophys Acta, 2012, 1826(2): 338-349. doi: 10,1016/ j.bbcan,2012.05.004.
  • 6Champ CE, Siglin J, Mishra MV, et al. Evaluating changes in radiation treatment volumes from post-operative to same- day planning MRI in High-grade gliomas [J]. Radiat Oncol, 2012, 7: 220. doi: 10,1186/1748-717X-7-220.
  • 7Chen S, Tanaka S, Giannini C, et al. Gliomatosis cerebri: clinical characteristics, management, and outcomes [J]. J Neurooncol, 2013, 112(2): 267-275. doi: 10,1007/sl 1060- 013-1058-x.
  • 8Zhan C, Li B, Hu L, et al. Micelle-based brain-targeted drug delivery enabled by a nicotine acetylcholine recep- tor ligand [J]. Angew Chem Int Ed Engl, 2011, 50(24): 5482-5485. doi: 10,1002/anie,201100875.
  • 9Lu W, Wan J, She Z, et al. Brain delivery property and ac- celerated blood clearance of cationic albumin conjugated pegylated nanoparticle [J]. J Control Release, 2007, 118(1): 38-53.
  • 10Bolhassani A. Potential efficacy of cell-penetrating peptides for nucleic acid and drug delivery in cancer [J]. Biochim Biophys Acta, 2011, 1816(2): 232-246. doi: 10,1016/ j.bbcan,2011.07.006.

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