摘要
目的评估细胞因子诱导的杀伤细胞（cytokine-induced killer cells,CIK）治疗中晚期泌尿生殖系统肿瘤的效果。方法对成都军区昆明总医院2005年6月—2010年2月收治的仅接受过手术治疗的38例中晚期泌尿生殖系统肿瘤行CIK治疗,比较治疗前后机体免疫状态变化、疗效及毒性反应、肿瘤标志物及生活质量变化。结果 2个疗程后,38例外周血免疫指标CD3^＋、CD56^＋、CD3＋CD56^＋T细胞百分率均较治疗前显著增高（P〈0.05）;临床缓解率达94.7%;相关肿瘤标志物（癌胚抗原、癌抗原125、乳酸脱氢酶及前列腺特异性抗原）水平均较治疗前显著下降（P〈0.01）;生存质量Karnofsky评分较治疗前平均提高10-20分,提高率为94.7%,平均体质量较治疗前增加1-2 kg。结论 CIK疗法为中晚期泌尿生殖系统肿瘤患者提供了一种可以延长生存期、提高生活质量的有效方法。
Objective To investigate the clinical curative effect of cytokine-induced killer cells（ CIK） in treatment of middle-late stage of urogenital neoplasms. Methods A total of 38 middle-late stage of urogenital neoplasms patients,who underwent only surgical treatment,were treated with CIK therapy during June 2005 and February 2010,and the changes of body＇s immune status,clinical effect and toxic reaction,tumor markers,and the changes of quality of life were compared before and after the treatment. Results After two courses of treatment for the 38 patients,peripheral blood of immune parameters CD3^＋,CD56^＋and CD3^＋CD56^＋T cell percentages were significantly higher than those before treatment（ P〈0. 05）; clinical remission rate was 94. 7%; related levels of tumor markers [carcinoembryonic antigen（ CEA）,cancer antigen 125,lactate dehydrogenase,prostate-specific antigen） ] were significantly decreased after treatment compared with those before treatment（ P 〈0. 01）. Karnofsky score for quality of life after treatment was increased at an average of 10 to 20 points compared with that before treatment,and the increase rate was 94. 7%,and average body mass after treatment increased 1-2 kg. Conclusion CIK therapy in treatment of middle-late stage of urogenital neoplasms may prolong life span and improve the quality of life.
出处
《解放军医药杂志》
CAS
2014年第11期64-67,共4页
Medical & Pharmaceutical Journal of Chinese People’s Liberation Army
基金
云南省应用基础研究自筹项目(2010ZC186)
