摘要
将50只SD雌性大鼠随机分为5组,连续给木瓜提取液12周后,测定大鼠Ⅰ型胶原(ColⅠ)、组织蛋白酶L(Cath L)、Ⅰ型前胶原氨基端前肽(PINP)、Ⅰ型胶原交联羧基末端肽(ICTP)并行股骨并进行形态学分析.结果表明:木瓜提取液组与雌激素组能显著增加大鼠的骨小梁的数量、降低Cath L的表达,木瓜高剂量组与雌激素组无明显差异(P>0.05),这一作用在高剂量组更加明显.木瓜提取液能够降低破骨细胞Cath L的表达来抑制骨基质中ColⅠ的分解,从而起到抗骨质疏松的疗效和骨保护作用.
Abstract. 50 SD female rats were divided in to 5 groups in a random way, continusly treated with papaya for 12 week, and the Rat Collagen I （Col I ）, Cathepsin L（Cath L）, procollagen IN- terminal propeptide （PINP）, carboxyterminal telopeptide of typ~ I collagen （ICTP） and morphology were determined. The following results obtained. The rats in group of papaya and group of estrogen obviously increased in number of bony trabecule , decreased in the Cath L expression. There were no difference between group of papaya wi：h high does and group of estrogen （P〉0.05） ,and it was more effective in high dose group. The results imply that the high does papaya can be able to decrease the Cath L expression of osteoc：ast, consequently inhibited the dissolve of Col I , result in protection of bone and antiosteoporosis
出处
《陕西师范大学学报（自然科学版）》
CAS
CSCD
北大核心
2014年第5期75-78,共4页
Journal of Shaanxi Normal University：Natural Science Edition
基金
国家自然科学基金资助项目(81173443)
