摘要
目的：探讨不同自然史毛细支气管炎婴幼儿预后与肺功能主要参数的关系。方法选取2011年1月-2012年12月唐山市妇幼保健院小儿呼吸科收治并经治疗出院的毛细支气管炎患儿160例，按照自然史不同分为两组：对照组77例，无特殊自然史；观察组83例，有湿疹、过敏史，或一级亲属有哮喘及变应性鼻炎病史。分别记录出院时、出院1年的肺功能参数及反复喘息、哮喘的情况，观察并比较两组患儿出院时及出院1年的病症评分情况。结果两组出院1年肺功能指标与出院时比较均下降，差异有高度统计学意义（P〈0.01），观察组各指标明显低于对照组，差异有统计学意义（P〈0.05）；观察组患儿出院1年反复喘息、哮喘发生率均高于对照组，差异有统计学意义（P〈0.05）；出院1年两组病症评分均高于出院时，观察组评分较对照组升高更明显，差异有统计学意义（P〈0.05）。结论有特殊自然史的毛细支气管炎患儿，肺功能恢复较无自然史患儿差，且易复发，出院1年内病症情况容易加重，故应密切监测，继续巩固治疗以减少复发。
Objective To discuss the relationship between prognosis of different natural history infants with capillary bronchitis and main parameters of lung function. Methods 160 cases of infants with capillary bronchitis treated in De-partment of Pediatrics, Maternal and Child Care Service Centre of Tangshan City from January 2011 to December 2012 were selected. According to the different natural history, patients were divided into control group （n=77）, who had no special natural history, and observation group （n = 83）, who had eczema, allergic history, asthma and allergic rhinitis history of first degree relative. The lung function parameters of patients hospitalization and 1 year after discharge, re-peated wheezing, asthma were recorded. The symptoms score of patients hospitalization and 1 year after discharge be-tween the two groups were compared . Results Compared with hospitalization , lung function parameters of patients 1 year after discharge significantly reduced, the difference was statistically significant （P〈0.01）, the observation group was lower than the control group, the difference was statistically significant （P〈0.05）. The rates of repeated wheezing, asthma in the observation group were higher than those in the control group, the differences were statistically significant （P〈0.05）. Compared with hospitalization, the symptoms score of patients 1 year after discharge significantly increased, and the observation group was higher than the control group, the difference were statistically significant （P 〈 0.05）. Conclusion Compared with infants without special natural history, the lung function recovery of infants with special natural history is worse, and easy to relapse, 1 year after discharge disease is easier to exacerbation, who should be closely monitored, and given consolidation therapy to reduce the recurrence rate.
出处
《中国医药导报》
CAS
2014年第35期20-24,共5页
China Medical Herald
基金
河北省自然科学基金计划项目(编号C20142206303)
关键词
毛细支气管炎
肺功能参数
反复喘息
Capillary bronchitis
Parameters of lung function
Repeated wheezing
