摘要
蒽醌类化合物(anthraquinones)是大黄、何首乌、决明子、芦荟等植物的主要活性成分,药理作用广泛,如泻下、抗菌、保肝利胆等。目前,含有蒽醌的中药或中成药广泛应用于便秘、慢性肾功能衰竭等多种疾病,但是由于服用含蒽醌成分的中药而引起大肠黑病变的报道日益增加,蒽醌类化合物的毒性越来越受到人们的重视。本研究总结了近年来对蒽醌毒理作用的基础及临床研究,对其在消化系统、泌尿系统、生殖系统中的毒性进行综述,为临床合理应用含有蒽醌的中药或中成药制剂提供参考。
Anthraquinones are the major active components of rhubarb, radix polygoni multiflori, semen cassiae, aloe vera and many other medicinal plants. They are widely used in the pharmaceutical industry due to its diarrhea, an-tibacterial, liver-protective and cholagogue properties. Present uses of Chinese medicine containing anthraquinones are for the treatment of constipation and chronic renal failure. However, there are more increased reports on melanosis coli as a result of using anthraquinones containing drugs, which, leads to increased research in the field. This paper focuses on the toxicological effects in digestive system, urinary system and reproductive system during these years. It is neces-sary and crucial to provide proper reference for safer clinical use of traditional Chinese medicines with anthraquinones components and Chinese medicine preparations.
出处
《中国医药导报》
CAS
2014年第35期160-162,F0003,共4页
China Medical Herald
基金
国家中医药行业科研专项项目(编号201307012)
关键词
蒽醌类化合物
毒性
中药
Anthraquinones
Toxicity
Traditional Chinese medicine
