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新型含氮杂环的酰基硫脲衍生物的合成 被引量:2

Synthesis of Acylthiourea Derivatives with Nitrogen Heterocyclic
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摘要 以取代苯甲酸为原料,经酰氯化和酰化反应制得取代苯甲酰基异硫氰酸酯(3);3与2-氨基-4-对硝基苯基噻唑经加成反应合成了5个含氮杂环的苯甲酰基硫脲衍生物,其中3个为新化合物,其结构经1H NMR,IR和元素分析表征。 Five acylthiourea derivatives with nitrogen heterocyclic( three of them are new compounds)were synthesized by addition reaction of 2-amino-4-p-nitrophenyl thiazole with benzoyl isothiocyanates which were prepared by chlorination and acylation from substituted benzoic acids. The structures were characterized by^1 H NMR,IR and elemental analysis.
出处 《合成化学》 CAS CSCD 2015年第1期80-82,共3页 Chinese Journal of Synthetic Chemistry
基金 广西教育厅高校科研资助项目(YB2014416) 广西高校优秀人才计划资助项目(RC2007043)
关键词 含氮杂环 酰基硫脲 2-氨基-4-对硝基苯基噻唑 合成 nitrogen heterocyclic acylthiourea 2-amino-4-p-nitrophenyl thiazole synthesis
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  • 1魏太保,陈继畴.固-液相转移催化法合成苯甲酰基异硫氰酸酯[J].化学世界,1994,35(11):583-585. 被引量:6
  • 2Moeker J, Teruya K, Rossit S, et al. Design and syn- thesis of thiourea compounds that inhibit transmem- brane anchored carbonic anhydrases [ J]. Bioorg Med Chem,2012,20:2392 - 2404.
  • 3Rob C A, Jan N M, Nico P E, et al. Comparative cy- totoxicity of N-substituted N'- ( 4-imidazole-ethyl ) -thio- urea in precision-cut rat liver slices [ J ]. Toxicology, 2004,197:81 -91.
  • 4Vandresen F, Falzirelli H, Sabrina A, et al. Novel R- ( + )-limonene-based thiosemicarbazones and their an- titumor activity against human tumor cell lines [ J ]. Eur J Med Chem,2014,79 : 110 - 116.
  • 5Serra S, Moineaux L, Vancraeynest C, et al. Thio- semicarbazide, a fragment with promising indolamine- 2,3-dioxygenase (IDO) inhibition properties [ J ]. Eur J Med Chem,2014,82:96 - 105.
  • 6Zhong Z, Xing R, Liu S, et al. Synthesis of acyl thiou- rea derivatives of chitosan and their antimicrobial activi- ties in vitro[ J]. Carbohydr Res ,2008 ,343 :566 - 570.
  • 7Kamal A, Ramakrishna G, Raju P, et al. Synthesis and anti-cancer activity of chaleone linked imidazolones [ J ]. Bioorg Med Chem Lett,2010,20:4865 - 4869.
  • 8Anthwal A, Rajesh U C, Rawat M S M, et al. Novel ne conjugates with potential to counter drug resistance in Trichomonas vaginalis [ J ]. Eur J Med Chem,2014,79:89-94.
  • 9Kima T H, Seo W D, Ryu H W, et al. Anti-tumor effects by a synthetic chalcone compound is mediated by c-mye-mediated reactive oxygen Species production [J]. Chem Biol Interact,2010,188:111 -118.
  • 10Shakil N A, Singh M K, Sathiyendiran M, et al. Mi- crowave synthesis, characterization and bio-efficacy e- valuation of novel chalcone based 6-carbethoxy-2-cy- clohexen-l-one and 2H-indazol-3-ol derivatives [ J ]. Eur J Med Chem, 2013,59 : 120 - 131.

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