摘要
目的：研究钙敏感受体（CaSR）和增殖细胞核抗原（PCNA）在非小细胞肺癌（NSCLC）中的表达及其意义。方法收集齐齐哈尔市第一医院胸外科2012～2013年手术标本，采用免疫组化法检测112例NSCLC组织及33例NSCLC癌旁组织中CaSR、PCNA的表达情况。结果 CaSR和PCNA在NSCLC组织中的表达（86.36%、84.82%）明显高于癌旁组织（15.15%、24.24%），差异均有统计学意义（P〈0.05）。 CaSR与PCNA的表达水平与TNM分期、肿瘤大小、肿瘤分化及有无淋巴结转移有关（P〈0.05或P〈0.01），与年龄、性别和肿瘤分型无关（P〉0.05）。在NSCLC组织中CaSR与PCNA的表达呈正相关（r=0.401，P〈0.01）。结论 CaSR和PCNA在NSCLC组织中的表达异常增高，并且具有较好的相关性，CaSR可能参与肺癌的增殖与分化，促进肺癌的发生发展。
Objective To investigate the expression and clinical significance of calcium sensing receptor （CaSR） and proliferating cell nuclear antigen （PCNA） in non-small cell lung cancer （NSCLC）. Methods The surgical samples in the Department of Thoracic Surgery, the First Hospital of Qiqihar from 2012 to 2013 were collected. The expression of CaSR and PCNA were detected in 112 paraffin-embedded NSCLC tissues and 33 adjacent normal lung tissues （control group） using immunohistochemistry. Results The expression levels of CaSR and PCNA （86.36%, 84.82%） were dis-tinctly higher in NSCLC than those in the control group （15.15%, 24.24%）, the differences were statistically significant （P〈 0.05）. The expression of CaSR and PCNA in NSCLC were significantly correlated with tumor differentiation, TNM stage, tumor size and lymph node metastasis （P〈0.05 or P〈0.01） and not correlated with age, gender, tumor types （P〉0.05）. The expression of CaSR was positive correlated with PCNA in NSCLC （r = 0.401, P〈 0.01）. Conclusion CaSR expression is correlated with PCNA expression, CaSR has an important function in NSCLC, and promotes the occur-rence and development of NSCLC.
出处
《中国医药导报》
CAS
2015年第1期27-29,38,F0004,共5页
China Medical Herald
基金
黑龙江省大学生创新创业训练计划项目(编号201311230031)
