摘要
目的:调查郑州市儿童医院2013年门诊处方超说明书用药现状,为促进儿童合理用药提供依据。方法:采用系统随机抽样方法抽取2013年门诊处方,根据药品说明书的内容,判断处方医嘱是否存在超说明书用药,并对处方抽样情况、超说明书用药类型、各年龄段超说明书用药发生率和药品种类进行统计分析。结果:共纳入8 684张处方,涉及410种药品,含16 344条医嘱记录,其中超说明书用药处方、品种和医嘱的比例依次为70.87%、71.95%、51.21%。超说明书用药类型主要有超适用人群(50.83%)、超给药剂量(21.00%)和超给药频次(19.04%)。超说明书用药发生年龄段排名前3位为新生儿(63.27%)、婴幼儿(56.20%)、学龄期(44.98%)。超说明书用药品种排名前5位为:心血管系统用药(99.02%)、抗感染药(64.14%)、维生素和矿物质类药(62.89%)、血液系统用药(59.48%)、中成药(53.43%)。结论:该院门诊处方超说明书用药现象较为普遍,医师要严格把握说明书规定的适应证、用法用量,选择合适的药物剂型,减少超说明书用药,以保障儿童安全用药。
Objective：To investigate the off-label drug use in the outpatients of Zhengzhou children＇s hospital in 2013 to provide the evidence for improving the rational drug use in pediatrics. Methods：The prescriptions of outpatients were randomly selected from January to December in 2013. According to the drug instruction, the off-label drug uses were analyzed in the following aspects： sam-pling conditions, the kinds of off-label drug use, the incidence of off-label drug use in different age groups and drug categories. Re-sults：A total of 8 684 prescriptions with 16 344 medical records involving 410 kinds of drugs were analyzed, and the rate of off-label drug use was 70. 87% for prescription, 51. 21% for medical orders and 71. 95% for category, respectively. The primary types of off-label drug use were over applicable people （50. 83%）, dosage（21. 00%） and frequency （19. 04%）. The top 3 age groups with high-est off-label drug use rate were neonates （63. 27%）, infants （56. 20%） and school-age （44. 98%）. The top 5 drugs with highest off-label drug use rate were cardiovascular system medicines （99. 02%）, anti-infective agents （64. 14%）, vitamin and mineral drugs （62. 89%）, hematological system medicines （59. 48%） and Chinese patent drugs （53. 43%）. Conclusion： Off-label drug use in outpatients is prevalent. Physicians should master indications, usage and dosage described in instructions, select suitable dosage form, reduce off-label drug use and improve drug safety in pediatrics.
出处
《中国药师》
CAS
2015年第1期116-118,共3页
China Pharmacist
基金
常州四药临床药学科研项目"儿童医院超说明书用药现象调查分析"(编号:CZSYJJ13016)
关键词
儿童用药
门诊
超药品说明书用药
合理用药
Children’ s medicine
Outpatient
Off-label drug use
Rational drug use
