摘要
目的探讨七叶皂苷钠联合伐昔洛韦治疗中老年带状疱疹的疗效。方法 120例患者均为门诊或住院部中老年带状疱疹患者,将其随机分为A、B、C三组,每组40例。其中,A组采用基础治疗方案,即口服伐昔洛韦(每次0.3 g,每日2次)和甲钴胺(每次0.5 mg,每日3次),外加莫匹罗星软膏每日2次外搽;B组和C组采用与A组相同治疗方案的同时,分别加用地塞米松(5mg/d)或七叶皂苷钠(20 mg/d)静脉滴注治疗,3组疗程均为9 d。结果治疗后B组和C组疗效显著高于A组,比较差异有统计学意义(qA-B=3.72,P<0.05和qA-C=3.51,P<0.05),而B组和C组间疗效比较差异无统计学意义(qB-C=1.29,P>0.05)。治疗后B组和C组患者的疼痛缓解时间、止痛时间、结痂时间、VAS评分明显低于A组(P均<0.01),C组疼痛缓解时间低于B组,而B、C两组的止痛时间、结痂时间比较差异无统计学意义(P>0.05)。C组患者疱疹后遗神经痛(PHN)发生率显著低于A组,比较差异有统计学意义(χ2=4.30,P<0.017)。结论对中老年带状疱疹患者早期给予七叶皂苷钠治疗,不但可收到较好的疗效,而且可以减少PHN的发生,同时又能避免应用糖皮质激素可能产生的不良反应。
Objective To investigate the clinical efficacy of sodium aescinate in combination with va-laciclovir in the treatment of herpes zoster in middle-aged and elderly patients. Method A total of 120 cases of herpes zoster admitted to the in-patients and out-patients in hospital were randomly divided into groups A,B and C （n=40 for each group）. Patients in group A received basic treatment including oral intake of valaciclov-ir （0. 3 g,twice a day）,orally mecobalamine （0. 5 mg,three times a day）and external topical use of mupiro-cin ointment twice a day. Patients in groups B and C were treated with dexamethasone 5 mg/d i. v. drip or so-dium aescinate 20 mg/d i. v. drip,besides the basic treatment delivered in group A. The course of treatment endured for 9 days. Results The therapeutic effects in groups B and C were significantly higher than that in group A （qA-B =3. 72,P0. 05）. The time of pain relief,time of analgesia,time of scarring and VAS in both groups B and C were remarkably shorter and lower than those in group A （all P0. 05 ）. Finally,the inci-dence of postherpetic neuralgia （PHN）in group C was significantly lower than that in group A （χ2 =4. 30,P〈0. 017）. Conclusions The application of sodium aescinate is efficacious in the treatment of early-stage her-pes zoster in middle-aged and elderly patients. Moreover,it reduces the incidence of PHN and prevents the oc-currence of adverse events induced by use of glucocorticoid.
出处
《新医学》
2014年第12期824-827,共4页
Journal of New Medicine
关键词
七叶皂苷钠
带状疱疹
后遗神经痛
Sodium aescinate Herpes zoster Postherpetic neuralgia
