摘要
目的 探讨妊娠期糖尿病患者血浆抵抗素水平与新生儿结局的相关性，以期通过相关代谢指标异常识别高危病人及预测新生儿结局。方法 选取2012年3月至2014年3月北京市顺义区顺义中医医院产科门诊产检的中晚期孕妇做为研究对象，分妊娠期糖尿病患者（ GDM组）和健康孕妇两组，分别测定两组孕妇的血浆抵抗素，观察两组新生儿出生体重，新生儿红细胞增多症，新生儿并发症发生率。结果 妊娠期糖尿病患者血浆抵抗素水平与新生儿体重呈显著正相关（r＝0．817，P＜0．05），妊娠糖尿病组血浆抵抗素水平和新生儿出生体重显著高于健康组（t值分别为3．92、2．63，均P＜0．01），且妊娠糖尿病组巨大儿、新生儿并发症和新生儿红细胞增多症发生率均显著高于健康组（χ^2分别为11．07、13．41、7．66，均P＜0．01），妊娠期糖尿病患者和健康孕妇血浆抵抗素水平对新生儿不良结局均呈显著正相关（r值分别为0．804、0．219，均P＜0．05）。妊娠糖尿病组新生儿转诊率、早产率、新生儿呼吸窘迫综合征发生率和新生儿高胆红素血症发生率均显著高于健康组（χ^2分别为8．01、11．68、7．55、7．19，均P＜0．05），而两组新生儿死亡率和新生儿低血糖发生率无显著性差异（χ^2分别为6．78、5．71，均P＞0．05）。结论 妊娠期糖尿病患者血浆抵抗素水平与新生儿结局具有显著相关性，可以利用妊娠期糖尿病患者的相关代谢指标预测新生儿并发症与死亡率。
Objective To study the correlation between plasma resistin levels of gestational diabetes mellitus （ GDM） patients and neonatal outcomes, so as to identify the high-risk patients and predict neonatal outcomes through related metabolism indexes .Methods Pregnant women at second or third trimester visiting the obstetric department of Traditional Chinese Medicine Hospital of Shunyi District in Beijing during March 2013 and March 2014 were selected and were divided into GDM group and healthy group .Plasma resistin levels of pregnant women were determined and the birth weight and incidence of newborn complications and neonatal polycythemia were observed in two groups.Results The plasma resistin levels of GDM patients were positively correlated with birth weight （r=0.817, P〈0.05）, and the plasma resistin levels and birth weight of GDM group were significantly higher than those of healthy group （ t value was 3.92 and 2.63, respectively, both P〈0.01）.The incidence of macrosomia, neonatal complications and neonatal polycythemia was significantly higher in GDM group than in healthy group （χ^2value was 11.07, 13.41 and 7.66, respectively, all P〈0.01）.Plasma resistin levels of GDM patients and healthy pregnant women was positively correlated with neonatal adverse outcomes （r value was 0.804 and 0.219, respectively, both P〈0.05）.In GDM group neonatal referral rate , premature birth rate and the incidence of neonatal respiratory distress syndrome and neonatal hyperbilirubinemia were significantly higher than those in healthy group （χ^2value was 8.01, 11.68, 7.55 and 7.19, respectively, all P〈0.05）, but there was no significant difference in incidence of neonatal mortality and neonatal hypoglycemia between two groups （χ^2value was 6.78 and 5.71, respectively, both P 〉0.05）.Conclusion Plasma resistin levels of GDM patients are significantly correlated with neonatal outcomes .The related metabolism indexes of GDM patients can be used to predict the incidence of neonatal complications and neonatal mortality .
出处
《中国妇幼健康研究》
2014年第6期999-1002,共4页
Chinese Journal of Woman and Child Health Research
关键词
妊娠期糖尿病
抵抗素
新生儿结局
相关分析
回归分析
gestational diabetes mellitus （GDM）
resistin
neonatal outcomes
correlation analysis
regression analysis
