期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

血清ykl-40在宫颈癌诊断分期及疗效判断中的临床价值

原文传递
导出
摘要 目的探讨血清ykl-40在宫颈癌中的临床价值。方法采用酶联免疫吸附试验检测53例宫颈癌、35例宫颈上皮内瘤变患者及35名健康妇女的血清ykl-40的水平。结果宫颈癌组、宫颈上皮内瘤变组及健康妇女组(对照组)血清中ykl-40浓度的中位数分别为194.37、69.51和74.51 ng/m L。ykl-40浓度比较,宫颈癌组与其他两组之间差异均有统计学意义(P<0.01);正常对照组与宫颈上皮内瘤变组差异无统计学意义(P>0.05)。III/IV期宫颈癌患者血清ykl-40浓度高于I/II期患者(P<0.01)。44例I/II期宫颈癌术前血清ykl-40浓度的中位数178.25 ng/m L与术后163.92 ng/m L比较,差异有统计学意义(P<0.05)。结论血清ykl-40在宫颈癌的诊断、临床分期及手术治疗疗效判断方面均有一定的临床价值。
作者 董晓霞 陈育梅 吕杰强 方深慧 黄凌霄
机构地区 温州医科大学温州市第三临床学院(温州市人民医院)
出处 《浙江预防医学》 2015年第1期93-95,共3页 Zhejiang Journal of Preventive Medicine
基金 温州市科技计划项目(Y20130124)
关键词 YKL-40 宫颈癌 酶联免疫吸附试验
分类号 R730.43 [医药卫生—肿瘤] R737.33 [医药卫生—肿瘤]
  • 相关文献

参考文献9

  • 1Johansen JS, Bojesen SE, Price PA, et al. Plasma YKL -40 and total and disease - specific mortality in the general population [J]. ClinChem, 2010, 56 (10): 1580-1591.
  • 2王秀玲,卢美松.YKL-40在妇科肿瘤中的研究新进展[J].医学综述,2012,18(13):2025-2027. 被引量：5
  • 3Corradi M, Goldoni M, Alinovi R, et al. YKL- 40 and Mesothelin in the Blood of Patients with Malignant MesotheliomaLung Cancer and Asbestosis [ J ]. Anticancer research, 2013, 33 (12) : 5517 -5524.
  • 4Wang D, Zhai B, Hu F, et al. High YKL- 40 Serum Concentration Is Correlated with Prognosis of Chinese Patients with Breast Cancer [J]. PloS one, 2012, 7 (12) : e51127.
  • 5Itik V, Kemik O, Kemik A, et al. Serum YKL- 40 Levels in Patients with Gastric Cancer [J]. Biomark Cancer , 2011 (3) : 25 - 30.
  • 6Zou L, He X, Zhang JW, et al. The efficacy of YKL -40 and CA125 as biomarker for epithelial ovarian cancer [ J]. Braz J Med Biol Res, 2010, 43 (12) : 1232 -1238.
  • 7Peng C, Peng J, Jiang L, et al. YKL -40 protein levels and clinical outcome of human endometrial cancer [ J ]. J Int Med Res, 2010, 38 (4): 1448-1457.
  • 8Johansen JS, Roslind A, Pallc C, et al. Serum YKL - 40 levels in patient with cervical cancer are elevated compared to patients with cervical intraepithelial neoplasia and healthy control [ C ]. ASCO Annal Meeting, 2006: 267.
  • 9Mitsuhashi A, Matsui H, Usui H, et al. Serum YKL -40 as a marker for cervical adenocarcinoma [ J ]. Ann Oncol, 2009, 20 (1): 71 -77.

二级参考文献27

  • 1Johansen ,IS, Williamson MK, Rice JS, et al. Identification of pro- teins secreted by human osteoblastic cells in culture [J]. J Bone Miner Res, 1992,7 (5) :501-512.
  • 2Hakala BE, White C, Recklies AD. Human cartilage gp-39, a major secretory product of articular chondrocytes and synovisl cells, is a mammalian member of a chitinase protein family [ J ]. Bid Chem, 1993,268 (34) :25803-25810.
  • 3Johansen JS, Larsen LA, Price PA, et al. YKL-40 Protein expres- sion in the early developing human musculoskeletal system [ J ]. Histochem Cytochem ,2007,55 ( 12 ) : 1213-1228.
  • 4Johansen JS, Schultz NA, Jensen BV, et al. Plasma YKL-40 : a po- tential new cancer biomarker? [ J ]. Future Oncol, 2009,5 ( 7 ) : 1065-1082.
  • 5Bojesen SE,Johansen JS, Nordestgaard BG. Plasma YKL-40 levels in healthy subjects from the general population[ J]. Clin Chim Ac- ta,2011,412(9/10)709-712.
  • 6Johansen JS, Pedersen AN, Schroll M, et al. High serum YKL-40 level in a cohort of octogenarians is associated with increased risk of all-cause mortality [ J ]. Clin Exp Immunol, 2008,151 ( 12 ) : 260 - 266.
  • 7Ringsholt M, HogdM1 EV, Johansen JS, et al. YKL-40 protein ex- pression in normal adult human tissues an immunohistochemical study[ J]. J Mol Hist ,2007,38 ( 1 ) :33-43.
  • 8Nutt CL,Betensky RA,Brewer MA,et al. YKL-40 is a differ-renti- ated diagnostic marker for histologic subtypes of high-gracle gliomas [J]. Clin Cancer Res,2005,11 (6) :2258-2264.
  • 9Kolson DL. YKL-40 : a candidate biomarker for simian immunodefi- cienly virus and human immunodeficienly virus encephalitis? [J].Am J Patho1,2008,173 (1) :25-29.
  • 10Ling H, Recklies AD. The chitinase 3-like protein human cartilage 39 ( HC-39 ) inhibits celluar responses to the inflammatory cytokines interleukin-1 and tumor necrosis factor alpha [ J ]. Bio Chem,2004, 380(Pt 3) :651-659.

共引文献4

浙江预防医学
2015年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部